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Gene Expression Profile Analysis of Colon Cancer Grade Ii Into Grade Iii Transition by Using System Biology



Rostaminejad M1 ; Tavirani SR2 ; Mansouri V2 ; Jahanisherafat S3 ; Farshi HM4
Authors
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Authors Affiliations
  1. 1. Gastroenterology, Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Microbiology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2019

Abstract

Aim: Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology. Background: Colon cancer is one of lethal cancer in men and women. Treatment in advanced colon cancer is difficult and survival rate is low. Methods: Gene expression profiles of children patients with non-preforated appendicitis in comparison with the samples with non-appendicitis abdominal pain are analysis via protein - protein interaction PPI and the critical compounds are introduced by STITCH. Results: Six critical genes including MAPK3, AKT1, SRC, TP53, GAPDH, and ALB were identified as a possible biomarker panel related to colon cancer grade II to III transition. Among these critical genes roles of MAPK3, AKT1, SRC, TP53 are highlighted. Conclusion: It was concluded that target therapy to regulate SRC and TP53 may be the effective therapeutic way to treatment of colon cancer and more researches in necessary to design drugs for these purposes. © 2019 Research Institute for Gastroenterology and Liver Diseases .All Rights Reserved.
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