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Anticancer Activity of Naringenin on Human Liposarcoma: An Experimental and Bioinformatic Study Publisher Pubmed



Asghariazar V1 ; Karimi A2 ; Adeli S8 ; Kadkhodayi M3, 4 ; Zare E5 ; Vajdi M6 ; Nasimi Doost Azgoomi R7 ; Asghari Vostakolaei M7
Authors
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Authors Affiliations
  1. 1. Cancer Immunology and Immunotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  2. 2. Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Immunology Research Center Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Animal Biology, Faculty of Natural Sciences, The University of Tabriz, Tabriz, Iran
  5. 5. Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  6. 6. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  8. 8. Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Prostaglandins and Other Lipid Mediators Published:2024


Abstract

Naringenin (NAR) has shown potential as a cancer treatment, reducing cell proliferation and invasion in soft tissue sarcomas like liposarcoma (LPS). This study investigates NAR's role and molecular mechanism. Bioinformatic analysis was performed to assess the expression level of genes in LPS based on the GEO dataset. The heat map and PPI of genes were also analyzed. MTT, wound healing, DAPI staining, and flow cytometry evaluated the cell viability, migration, and apoptosis. Besides, real-time PCR was used to measure the NAR's impact on the expression levels of EMT, apoptosis, inflammation, and metastasis-related genes. The results showed that NAR reduces cell viability, proliferation, and migration but induces apoptosis in LPS cells. RT-PCR results revealed that NAR is capable of regulating the expression level of the apoptosis, EMT, migration, and Inflammation-related genes. This study demonstrated that NAR may play a crucial role in reducing cell viability, inducing apoptosis, and attenuating migration in Sw872 LPS cells. Consequently, NAR might be a promising and efficient factor in the treatment of LPS. © 2024 Elsevier Inc.
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