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Functional Roles of Lncrna-Tug1 in Hepatocellular Carcinoma Publisher Pubmed



Farzaneh M1 ; Ghasemian M2 ; Ghaedrahmati F3 ; Poodineh J4 ; Najafi S5 ; Masoodi T6 ; Kurniawan D7 ; Uddin S8 ; Azizidoost S9
Authors
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Authors Affiliations
  1. 1. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Clinical Biochemistry, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cancer Research Department, Sidra Medicine, Doha, 26999, Qatar
  7. 7. Laboratory Animal and Stem Cells, PT Bio Farma (Persero), West Java, Bandung, 40161, Indonesia
  8. 8. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar
  9. 9. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Life Sciences Published:2022


Abstract

Hepatocellular carcinoma (HCC) or hepatoma is malignant cancer that starts from the main liver cells. Although various classical methods have been used for patients with HCC, various molecular mechanisms involved in HCC progression should be invested. Previous studies demonstrated that abnormal expression of long non-coding RNAs (lncRNAs) presented important roles in the pathogenesis of HCC cells. LncRNA TUG1 was found to mediate HCC cell growth, EMT, and metastasis. Therefore, targeting TUG1 and its downstream genes may be a suitable approach for patients with HCC. In this review, we summarized the potential roles of TUG1 in HCC. © 2022
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