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Micrornas in Female Infertility: An Overview Publisher Pubmed



Bahmyari S1 ; Jamali Z2 ; Khatami SH3 ; Vakili O4 ; Roozitalab M5 ; Savardashtaki A6 ; Solati A1 ; Mousavi P7 ; Shabaninejad Z8, 9 ; Vakili S10 ; Behrouj H11 ; Ghasemi H12 ; Movahedpour A6
Authors
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Authors Affiliations
  1. 1. Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  8. 8. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  9. 9. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  11. 11. Department of Clinical Biochemistry, Behbahan Faculty of Medical Sciences, Behbahan, Iran
  12. 12. Department of Clinical Biochemistry, Abadan University of Medical Sciences, Abadan, Iran

Source: Cell Biochemistry and Function Published:2021


Abstract

Infertility impacts a considerable number of women worldwide, and it affects different aspects of family life and society. Although female infertility is known as a multifactorial disorder, there are strong genetic and epigenetic bases. Studies revealed that miRNAs play critical roles in initiation and development of female infertility related disorders. Early diagnosis and control of these diseases is an essential key for improving disease prognosis and reducing the possibility of infertility and other side effects. Investigating the possible use of miRNAs as biomarkers and therapeutic options is valuable, and it merits attention. Thus, in this article, we reviewed research associated with female diseases and highlighted microRNAs that are related to the polycystic ovary syndrome (up to 30 miRNAs), premature ovarian failure (10 miRNAs), endometriosis (up to 15 miRNAs), uterine fibroids (up to 15 miRNAs), endometrial polyp (3 miRNAs), and pelvic inflammatory (6 miRNAs), which are involved in one or more ovarian or uterine disease-causing processes. © 2021 John Wiley & Sons Ltd
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