Micrornas in Female Infertility: An Overview Publisher Pubmed



Bahmyari S¹ ; Jamali Z² ; Khatami SH³ ; Vakili O⁴ ; Roozitalab M⁵ ; Savardashtaki A⁶ ; Solati A¹ ; Mousavi P⁷ ; Shabaninejad Z^{8, 9} ; Vakili S¹⁰ ; Behrouj H¹¹ ; Ghasemi H¹² ; Movahedpour A⁶
Source: Cell Biochemistry and Function Published:2021

Abstract

Infertility impacts a considerable number of women worldwide, and it affects different aspects of family life and society. Although female infertility is known as a multifactorial disorder, there are strong genetic and epigenetic bases. Studies revealed that miRNAs play critical roles in initiation and development of female infertility related disorders. Early diagnosis and control of these diseases is an essential key for improving disease prognosis and reducing the possibility of infertility and other side effects. Investigating the possible use of miRNAs as biomarkers and therapeutic options is valuable, and it merits attention. Thus, in this article, we reviewed research associated with female diseases and highlighted microRNAs that are related to the polycystic ovary syndrome (up to 30 miRNAs), premature ovarian failure (10 miRNAs), endometriosis (up to 15 miRNAs), uterine fibroids (up to 15 miRNAs), endometrial polyp (3 miRNAs), and pelvic inflammatory (6 miRNAs), which are involved in one or more ovarian or uterine disease-causing processes. © 2021 John Wiley & Sons Ltd