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The Use of Proton Mr Spectroscopy in Epilepsy: A Methodological Review Publisher



Mobarakeh NM1, 2 ; Fadaie F3 ; Zadeh MRN2 ; Habibabadi JM4 ; Rad HS1, 2
Authors
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Authors Affiliations
  1. 1. Quantitative Medical Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran, Iran
  2. 2. Department of Biomedical Engineering and Medical Physics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epilepsy, Pars Hospital, Tehran, Iran
  4. 4. Department of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Frontiers in Biomedical Technologies Published:2019


Abstract

Magnetic Resonance Spectroscopy (MRS) has at least two major roles in the evaluation of epileptic patients. First, MRS can help to understand the interaction between seizures and metabolic function. Thus, MRS is particularly interesting for basic science studies of seizures and epilepsy. Second, MRS can explain the nature of seizure control and/or provide localization information by measuring metabolic changes. So MRS can be used as a powerful complementary technique to structural MRI for diagnosis and assessment of response to therapy, and measurement of disease progression. The aim of this paper is to review the methodological aspects of 1H-MRS publications between 1994 to 2016, which utilized 1H-MRS in lateralizing the epileptogenic zone in lesional and non-lesional Temporal Lobe Epilepsy (TLE), Extra-Temporal Lobe Epilepsy (ETLE), and generalized epileptic patients to help the spectroscopist, magnetic resonance imaging technologists, and radiologists to improve the overall diagnostic sensitivity in epileptic patients. © Tehran University of Medical Sciences
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