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Intestinal Leishmaniasis in Acquired Immunodeficiency Syndrome



Molaei M1 ; Minakari M2 ; Pejhan S1 ; Mashayekhi R1 ; Modaress Fatthi AR1 ; Zali MR3
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Research Center of Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Departments of Gastroenterology and Hepatology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Gastroenterology, Research Center of Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Source: Iranian Red Crescent Medical Journal Published:2011

Abstract

In endemic regions, visceral leishmaniasis is one of the most common opportunistic infections in HIV positive patients. Simultaneous infection with Leishmania and HIV has been reported in some countries but this is the first report of such a case in Iran. Our patient was a 27 years old man with intermittent night fever, abdominal pain, loss of appetite, vomiting, watery diarrhea and severe weight loss for 6 months. He had low socio-economic status with an imprisonment history. The patient was quite cachectic and had low grade fever. Physical exam and upper GI endoscopy revealed oropharyngeal candidiasis. Microscopic evaluation of duodenal biopsy material showed Leishmania amastigotes in macrophages of lamina propria. Leishman bodies were also observed in bone marrow aspiration specimen. Serologic tests were positive for Leishmania infantum. HIV antibody was also positive with a CD4+cell count of 80/μl. The diagnosis was acquired immunodeficiency syndrome with simultaneous visceral leishmaniasis involving intestinal mucosa. © Iranian Red Crescent Medical Journal.
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