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Autoimmunity in Common Variable Immunodeficiency: Epidemiology, Pathophysiology and Management Publisher Pubmed



Azizi G1, 2, 3 ; Abolhassani H2, 4 ; Asgardoon MH2, 5 ; Alinia T2 ; Yazdani R6 ; Mohammadi J7 ; Rezaei N2 ; Ochs HD8 ; Aghamohammadi A2, 3
Authors
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Authors Affiliations
  1. 1. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
  5. 5. Iranian Student Society for Immunodeficiencies, Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
  8. 8. Seattle Children’s Research Institute and Department of Pediatrics, University of Washington, Seattle, WA, United States

Source: Expert Review of Clinical Immunology Published:2017


Abstract

Introduction: Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency. Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infiltrates, malignancy, inflammatory and autoimmune conditions are also prevalent. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and creates difficulties in the management of autoimmune complications affecting these patients. Expert commentary: The management of autoimmunity in patients with CVID requires special considerations because dysregulation and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
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