Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine

Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine Publisher Pubmed

Ghasemi M¹ ; Mehranfard N²

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1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Neurophysiolog Research Center, Urmia University of Medical Sciences, Urmia, Iran

Source: Neuropharmacology Published:2018

Abstract

Norepinephrine (NE) has been shown to exert a potent suppressant effect on seizure development. On the other hand, several lines of evidence have shown that increased NE level is proconvulsant under certain conditions. These data suggest that variations in NE levels could affect modulatory action of noradrenergic system on seizures. Less, however, is known about the mechanisms by which adrenergic pathways protect against seizures or promote seizures. Knowing the mechanisms involved in anti- or proconvulsive effects of NE may help to the development of new therapeutic candidates for patients with refractory epilepsy. Here, we present some possible mechanisms involved in actions of NE on seizures. © 2018 Elsevier Ltd

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Maedeh Ghasemi (5)

Behzad Nazemroaya (2)

Style	Citing Format
MLA	Ghasemi M, Mehranfard N. "Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine." Neuropharmacology, vol. 137, no. , 2018, pp. 297-308.
APA	Ghasemi M, Mehranfard N (2018). Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine. Neuropharmacology, 137(), 297-308.
Chicago	Ghasemi M, Mehranfard N. "Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine." Neuropharmacology 137, no. (2018): 297-308.
Harvard	Ghasemi M, Mehranfard N (2018) 'Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine', Neuropharmacology, 137(), pp. 297-308.
Vancouver	Ghasemi M, Mehranfard N. Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine. Neuropharmacology. 2018;137():297-308.
BibTex	@article{ author = {Ghasemi M and Mehranfard N}, title = {Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine}, journal = {Neuropharmacology}, volume = {137}, number = {}, pages = {297-308}, year = {2018} }
RIS	TY - JOUR AU - Ghasemi M AU - Mehranfard N TI - Mechanisms Underlying Anticonvulsant and Proconvulsant Actions of Norepinephrine JO - Neuropharmacology VL - 137 IS - SP - 297 EP - 308 PY - 2018 ER -

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