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Efficacy of the Punica Granatum Peels Aqueous Extract for Symptom Management in Ulcerative Colitis Patients. a Randomized, Placebo-Controlled, Clinical Trial Publisher Pubmed



Kamali M1 ; Tavakoli H2 ; Khodadoost M1 ; Daghaghzadeh H2 ; Kamalinejad M3 ; Gachkar L4 ; Mansourian M5 ; Adibi P2
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Authors Affiliations
  1. 1. School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Infectious Disease and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Complementary Therapies in Clinical Practice Published:2015


Abstract

Objective: To investigate the effects of the Punica granatum peel extract on symptoms of patients with ulcerative colitis (UC). Method: Patients with UC were randomized to receive an aqueous extract of the P.granatum peel (6 g of dry peel/day) or placebo for four weeks complementary to standard medications. Symptoms were assessed using the Lichtiger Colitis Activity Index (LCAI) at baseline, week 4, and week 10 (follow-up). Clinical response was defined by ≥ 3 point decrease in LCAI. Results: The LCAI score was similarly reduced in both the P.granatum (-1.68 ± 3.85, P = 0.019) and placebo groups (-1.39 ± 2.41, P = 0.002). Clinical response was higher with P.granatum compared with placebo at week 4 (41.4% vs. 18.2%, P = 0.055), but not at week 10 (48.3% vs. 36.4%, P = 0.441). Conclusions: The P.granatum peel extract seems effective in complementary management of UC. Further studies in a larger sample of patients are warranted. IRCT2014040617156N1. © 2015 Elsevier Ltd.
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