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A Comparative Survey on the Expression of P16 As a Tumor Suppressor Protein in Cancerous and Non-Cancerous Colorectal Tissue Samples Using Immunohistochemistry Method



Dastjerdi MN1 ; Moeini M2
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Authors Affiliations
  1. 1. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Background: P16 is known as a tumor suppressor protein. This study was conducted to evaluate the association of P16 expression and pathogenesis of colorectal cancer. The presence of P16 in cancerous and non-cancerous colorectal tissue samples were thus compared using immunohistochemistry method. Methods: In this stud, 50 paired tissue samples were provided. The pairs were comprised of samples of cancerous colorectal tissue and normal peers from non-cancerous tissue adjacent to cancerous ones. Expression of P16 was studied on paraffined sections using immunohistochemistry method. Findings: Although P16 was expressed in all tissue samples, we found a lower expression in colorectal cancerous tissue in comparison with normal tissue samples. This difference was revealed to be statistically significant (P < 0.001). Conclusion: The presence of P16 can be regarded as an appropriate biological marker and a valuable prognostic factor for colorectal cancer.
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