Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Cardiovascular Effect of Pycnocycla Spinosa Decne. Exboiss. Var. Spinosa Extract in Anaesthetized Rat



Sadraei H1 ; Asghari G1 ; Hajhashemi V2 ; Nezami M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Daru Published:2006

Abstract

Hydroalcoholic extract of Pycnocycla spinosa Decne. exBoiss. var. spinosa has in vitro spasmolytic action, and at oral dose of 250μg/kg inhibits castor oil induced diarrhoea in mice. In this investigation, effects of P. spinosa var. spinosa extract in comparison with nifedipine on blood pressure and heart rate in animal model was studied. Injection of three bolus doses of P. spinosa var. spinosa extract (100μg/kg, 500μg/kg and 1mg/kg) into the jugular vein, temporary reduced blood pressure and heart rate. However, soon after completion of extract administration blood pressure and heart rate returned to normal. Nifedipine on the other hand caused a sustained reduction in blood pressure and decreased heart rate compared with the control group. From this study it was concluded that P. spinosa var. spinosa extract at antidiarrhoeal dose has no significant effect on blood pressure and heart rate.
Related Docs
View other Related Docs
1. Assessment of the Effect of Pycnocycla Spinosa Hydroalcoholic Extract on Rat Renal Function, Journal of Biological Sciences (2008)
2. Effect of Hydroalcoholic Extract of Pycnocycla Spinosa on Rat Isolated Bladder Contraction, Iranian Journal of Pharmaceutical Research (2004)
3. Antidiarrheal Action of Hydroalcoholic Extract of Pycnocycla Spinosa in Comparison With Loperamide and Dicyclomine, Iranian Journal of Pharmaceutical Research (2011)
4. Development of a Validated Hplc Method for Determination of an Active Component in Pycnocycla Spinosa and Tablets Prepared From Its Extract, Journal of HerbMed Pharmacology (2017)
5. 3,7,10,14,15-Pentaacetyl-5-Butanoyl-13,17-Epoxy-8-Myrsinene a Novel Compound Isolated From Pycnocycla Spinosa Extract With Potent Antispasmodic and Antidiarrheal Properties, Research in Pharmaceutical Sciences (2015)
6. Antispasmodic Effects of Pyenocycla Spinosa Seed and Aerial Part Extracts on Rat Ileum and Uterus Smooth Muscle Contractions, Daru (2008)
7. Bioactivity-Guided Isolation of Spasmolytic Components of Pycnocycla Spinosa Decne Ex Boiss, Research in Pharmaceutical Sciences (2011)
8. Bioassay Guided Fractionation of the Effect of Pycnocycla Spinosa Extract on Contraction of Rat Ileum, Journal of Isfahan Medical School (2014)
Experts (# of related papers)
View all Related Experts
Hassan Sadraei (22)
Gholamreza Asghari (22)
Other Related Docs
9. Relaxant Effect of Essential Oil and Hydro-Alcoholic Extract of Pycnocycla Spinosa Decne. Exboiss. on Ileum Contractions, Phytotherapy Research (2003)
10. Antispasmodic and Antidiarrhoeal Activities of 6-(4-Hydroxy-3- Methoxyphenyl)-Hexanonic Acid From Pycnocycla Spinosa Decne. Exboiss, Research in Pharmaceutical Sciences (2014)
11. Anti-Spasmodic Assessment of Hydroalcoholic Extract and Essential Oil of Aerial Part of Pycnocycla Caespitosa Boiss. & Hausskn on Rat Ileum Contractions, Research in Pharmaceutical Sciences (2016)
12. Spasmolytic Effect of Root and Aerial Parts Extract of Pycnocycla Spinosa on Neural Stimulation of Rat Ileum, Research in Pharmaceutical Sciences (2011)
13. Antispasmodic Effect of Three Fractions of Hydroalcoholic Extract of Pycnocycla Spinosa, Journal of Ethnopharmacology (2003)
14. Antidiarrheal Activities of Isovanillin, Iso-Acetovanillon and Pycnocycla Spinosa Decne Ex.Boiss Extract in Mice, Research in Pharmaceutical Sciences (2014)
15. New Diterpene Polyester and Phenolic Compounds From Pycnocycla Spinosa Decne. Ex Boiss With Relaxant Effects on Kcl-Induced Contraction in Rat Ileum, Phytochemistry Letters (2014)
16. Anti-Inflammatory Effect of Pycnocycla Spinosa Extract and Its Component Isoacetovanillone on Acetic Acid Induced Colitis in Rats, Research in Pharmaceutical Sciences (2015)
17. Bioassay-Directed Isolation of Falcarindiol and Isoacetovanillon From Pycnocycla Caespitosa Based on Kcl-Induced Contraction in Rat Uterus Smooth Muscles, Research in Pharmaceutical Sciences (2017)
18. Comparison of Antispasmodic Effects of Dracocephalum Kotschyi Essential Oil, Limonene and Α-Terpineol, Research in Pharmaceutical Sciences (2015)
19. Antispasmodic Effect of Dracocephalum Kotschyi Hydroalcoholic Extract on Rat Ileum Contraction, Research in Pharmaceutical Sciences (2015)
20. Assessment of Hydroalcoholic and Hexane Extracts of Rosa Persica Mich. Flower on Rat Ileum Spasm, Research in Pharmaceutical Sciences (2016)
21. Composition of the Essential Oil of Pycnocycla Spinosa Decne. Ex.Boiss. From Isfahan, Daru (2001)
22. Diurnal Variation of Essential of the Oil Components of Pycnocycla Spinosa Decne. Ex Boiss, Jundishapur Journal of Natural Pharmaceutical Products (2014)
23. Cardiovascular Effects of Cydonia Oblonga Miller (Quince), Evidence-based Complementary and Alternative Medicine (2022)
24. Antispasmodic Activity of Isovanillin and Isoacetovanillon in Comparison With Pycnocycla Spinosa Decne.Exboiss Extract on Rat Ileum, Research in Pharmaceutical Sciences (2014)
25. Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum Pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats, Iranian Journal of Pharmaceutical Research (2009)
26. Policosanol Supplementation Significantly Improves Blood Pressure Among Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2019)
27. Portulaca Oleracea Seeds Extract Does Not Prevent Dexamethasone-Induced Hypertension in Rats, Journal of HerbMed Pharmacology (2018)
28. The Effect of Dracocephalum Kotschyi Hydroalcoholic Extract on Biochemical and Hematological Parameters in Rat; [تأثیر عصارهی هیدروالکلی Kotschyi Dracocephalum روی پارامترهای بیوشیمیایی و هماتولوژیک رات], Journal of Isfahan Medical School (2022)