Impact of Positive Family History on the Survival of Breast Cancer in Iran Publisher



Makarian F¹ ; Ramezani MA² ; Ansari L³ ; Makarian S³
Source: International Journal of Cancer Research Published:2007

Abstract

To evaluate the influence of family history on the survival of breast cancer in Iranian women, the following study was designed. During 10 years from 1997-2007, 663 women with invasive breast cancer were selected from a private oncology clinic in Isfahan, prospectively. Both demographic variables and tumor characteristics was collected. Analysis was conducted by Cox regression model. A positive family history was found in 125 (19%) patients. Survival rate did not vary between subjects with positive and negative family history of breast cancer in both disease free and overall survival. Cox regression analysis after adjustment for other prognostic factors was determined that family history did not impact on the mortality rate of breast cancer. But lymph node involvement increased the relapse of tumor twice, approximately (RR = 1.9 95% CI = 1.35-2.77). Present findings did not demonstrate any association between breast cancer family history and the prognosis of cancer in Iranian women. It is important that is perceived the family history is a major risk factor for breast cancer but it does not effect on the survival and mortality rate of breast cancer. © 2007 Academic Journals Inc.