Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effectiveness of High-Intensity Laser Therapy for Pain and Function in Knee Osteoarthritis: A Randomized Controlled Trial Publisher



Taheri P1 ; Maghroori R1 ; Aghaei M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physical Medicine and Rehabilitation, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Middle East Journal of Rehabilitation and Health Studies Published:2024


Abstract

Background: High-intensity laser therapy (HILT) is still a controversial physical therapy modality for individuals with knee osteoarthritis (OA). Objectives: This study aimed to evaluate the effect of HILT on pain and function in patients with knee OA. Methods: This randomized controlled trial included 56 patients with knee OA referred to Amin Hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran, from April 19 to August 30, 2022. Patients were randomized into two groups (HILT and control), receiving isometric exercises targeting the quadriceps muscle, meloxicam 15 mg tablet, and Rahamin ointment for two weeks. The HILT group also received high-intensity laser irradiation three times a week for two weeks. The primary outcome was pain assessed using a Visual Analog Scale (VAS), and the secondary outcome was the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and its subscales (pain, stiffness, and physical function). Outcomes were evaluated at baseline, immediately, and three months after the last treatment session. Results: After adjusting for age, sex, and baseline values, immediately and three months after treatment, VAS pain scores were significantly lower in the HILT group than in controls (P < 0.001), with a large effect (standardized mean difference (SMD) =-1.22, 95% confidence interval (CI):-1.81;-0.62 and SMD =-1.31, 95% CI:-1.90;-0.70, respectively). The results were similar for WOMAC’s pain subscale. Despite the difference in WOMAC stiffness score was not significant between the two groups immediately after treatment (P = 0.135), this score was significantly lower in the HILT group than in the control group (SMD =-0.98, 95% CI:-1.56;-0.40, P = 0.002) three months after treatment. Furthermore, WOMAC physical function scores were significantly lower with HILT immediately and three months after treatment (P < 0.001). The same was true for the total WOMAC score. Conclusions: High-intensity laser therapy significantly improved pain and the WOMAC score in patients with knee OA immediately and three months after the last treatment session compared to the control group. © 2023, Author(s).
Related Docs
View other Related Docs
1. Low Level Laser Therapy in Knee Osteoarthritis: A Narrative Review, Advances in Therapy (2020)
2. Evaluation of the Effect of Elaeagnus Angustifolia Alone and Combined With Boswellia Thurifera Compared With Ibuprofen in Patients With Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial, Clinical Rheumatology (2017)
3. Evaluation of the Effects of Ankle Foot Orthosis on the Performance of the Subjects With Knee Joint Osteoarthritis, Physical and Occupational Therapy in Geriatrics (2024)
4. Comparison of Postoperative Pain and Clinical Outcomes of Total Knee Arthroplasty Among Patients With Rheumatoid Arthritis and Osteoarthritis Referred to Clinic or Emergency Department, Advanced Biomedical Research (2023)
5. Investigating the Effect of High Power Laser in Improving the Clinical Symptoms of Patients With Rotator Cuff Tendinopathy: A Randomized Clinical Trial, Middle East Journal of Rehabilitation and Health Studies (2024)
6. Comparison of the Effects of Acupuncture and Physical Modality on Symptoms of Knee Osteoarthritis, Journal of Isfahan Medical School (2012)
7. Effects of Total Knee Replacement on Quality of Life in 60-70 Year-Old Patients With Advanced Knee Osteoarthritis, Journal of Isfahan Medical School (2012)
8. Short-Time Influence of Totah Hip Arthroplasty on Patients With Sever Hip Ostheoarthritis, Journal of Isfahan Medical School (2013)
Experts (# of related papers)
View all Related Experts
Mehdi Motififard (8)
Reza Birang (4)
Other Related Docs
9. Evaluation of the Effectiveness of Topical Oily Solution Containing Frankincense Extract in the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, BMC Research Notes (2023)
10. No Difference Between Wound Closure in Extension or Flexion for Range of Motion Following Total Knee Arthroplasty: A Randomized Clinical Trial, Knee Surgery, Sports Traumatology, Arthroscopy (2016)
11. Effect of Additioning of Triamcinolon to Cocktail of Fentanil Epinephrinated Bupivacaine in Periarticular Injection for Post Operative Pain and Quality Improvement After Total Knee Arthroplasty, Journal of Isfahan Medical School (2011)
12. Pre-Emptive Injection of Peri-Articular-Multimodal Drug for Post-Operative Pain Management in Total Knee Arthroplasty: A Double-Blind Randomized Clinical Trial, International Orthopaedics (2017)
13. Does Knee Malalignment Predict the Efficacy of Realignment Therapy for Patients With Knee Osteoarthritis?, International Journal of Rheumatic Diseases (2017)
14. Comparative Efficacy of Laser Versus Conventional Method in the Success of Circumferential Supracrestal Fiberotomy in Orthodontic Patients: A Systematic Review, Journal of Lasers in Medical Sciences (2024)
15. Low-Level Laser Therapy and Myofacial Pain Dysfunction Syndrome: A Randomized Controlled Clinical Trial, Lasers in Medical Science (2009)
16. Ibuprofen and Low-Level Laser Therapy for Pain Control During Fixed Orthodontic Therapy: A Systematic Review of Randomized Controlled Trials and Meta-Analysis, Journal of Contemporary Dental Practice (2017)
17. Results of Old Posterior Crutiate Ligament (Pcl) Avulsion Fixation of Knee in St. Al-Zahra Hospital, Journal of Isfahan Medical School (2007)
18. The Knowledge of People Referred to Al-Zahra Hospital Orthopedic Clinic (Isfahan, Iran) About Risk Factors of Knee Osteoarthritis, Journal of Isfahan Medical School (2013)
19. Effects of Dry Needling on Pain in Patients With Knee Osteoarthritis: A Preliminary Study, Advanced Biomedical Research (2022)
20. Comparative Evaluation of Low-Level Laser and Systemic Steroid Therapy in Adjuvant-Enhanced Arthritis of Rat Temporomandibular Joint: A Histological Study, Dental Research Journal (2015)
21. Comparison of the Effects of Preoperative Celecoxib and Gabapentin on Pain, Functional Recovery, and Quality of Life After Total Knee Arthroplasty: A Randomized Controlled Clinical Trial, Journal of Research in Medical Sciences (2023)
22. Effect of Pulsed Electromagnetic Fields on Clinical Signs and Quality of Life in Patients With Hemophilic Arthropathy of the Knee Joint: A Randomized Controlled Trial, Advanced Biomedical Research (2020)
23. Comparing the Effectiveness of Kinesio Taping and Hand Exercise on Pain, Range of Motion and Grip Strength in Patients With Hand Osteoarthritis, Journal of Mazandaran University of Medical Sciences (2018)
24. Cross-Cultural Adaptation and Validation of the Persian Version of the Intermittent and Constant Osteoarthritis Pain Measure for the Knee, Iranian Journal of Nursing and Midwifery Research (2016)
25. Comparison of the Effects of 3-Point Valgus Knee Support and Lateral Wedge Insoles in Medial Compartment Knee Osteoarthritis, Iranian Red Crescent Medical Journal (2011)
26. Knee Injury and Osteoarthritis Outcome Score (Koos); Reliability and Validity in Competitive Athletes After Anterior Cruciate Ligament Reconstruction, Osteoarthritis and Cartilage (2011)
27. Predictors of Persistent Post-Surgical Pain Following Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Observational Studies, Pain Medicine (United States) (2023)
28. Thermal Effects of Laser-Osteotomy on Bone: Mathematical Computation Using Maple, Journal of Medical Signals and Sensors (2013)
29. Evaluation of the Efficacy of Piroxicam Gel in the Control of Pain and Erythema Caused by Fractional Co2 Laser Compared With Lubricant Gel, Journal of Isfahan Medical School (2011)
30. Effect of Low- Level Laser Therapy on Bone Regeneration of Critical-Size Bone Defects: A Systematic Review of in Vivo Studies and Meta-Analysis, Archives of Oral Biology (2020)
31. The Immediate Effects of Orthoses on Pain in People With Lateral Epicondylalgia, Pain Research and Treatment (2013)
32. Effect of Low-Level Laser Therapy on Dental Pain Induced by Separator Force in Orthodontic Treatment, Dental Research Journal (2013)
33. Effects of Dry Needling and Low-Power Laser for the Treatment of Trigger Points in the Upper Trapezius Muscle: A Randomized Clinical Trial, Journal of Chiropractic Medicine (2022)
34. Comparing Preemptive Injection of Peri-Articular-Multimodal Drug With Oral Celexocib for Postoperative Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2023)
35. A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis, Advances in Experimental Medicine and Biology (2021)
36. The Impacts of Low-Level Laser Therapy - a Complementary Treatment in the Management of Side Effects After Implant Surgery, Journal of Lasers in Medical Sciences (2018)
37. The Effect of Mulligan Mobilization Technique on Static and Dynamic Balance in Patients With Moderate to Severe Knee Osteoarthritis: A Randomized Controlled Clinical Trial, Journal of Rehabilitation Sciences and Research (2023)
38. Effectiveness of Low-Level Laser Irradiation in Reducing Pain and Accelerating Socket Healing After Undisturbed Tooth Extraction, Journal of Lasers in Medical Sciences (2020)
39. Responsiveness and the Minimal Important Change of Knee Injury and Osteoarthritis Outcome Score in Persian Patients With Knee Osteoarthritis Following Physiotherapy Intervention, Physiotherapy theory and practice (2022)
40. Reduced Morphine Consumption and Pain Severity With Transdermal Fentanyl Patches Following Total Knee Arthroplasty, Knee Surgery, Sports Traumatology, Arthroscopy (2014)
41. Efficacy of Photo Bio-Modulation Therapy for Pain Relief and Soft Tissue Wound Healing After Dental Implant Surgery: A Double-Blind Randomized Clinical Trial, Journal of Photochemistry and Photobiology (2021)
42. Does Low-Level Laser Photobiomodulation Improve Neurosensory Recovery After Orthognathic Surgery? a Clinical Trial With Blink Reflex, Journal of Oral and Maxillofacial Surgery (2021)
43. Evaluation of Three Methods for the Treatment of Dentin Hypersensitivity: A Randomised Clinical Trial, International Dental Journal (2024)
44. Evaluation of the Effects of 660-Nm and 810-Nm Low-Level Diode Lasers on the Treatment of Dentin Hypersensitivity, Journal of Lasers in Medical Sciences (2020)
45. The Home-Based Mirror Therapy in the Reduction of Phantom Limb Pain in Unilateral Below-Knee Amputees, Journal of Neurosciences in Rural Practice (2024)
46. The Effectiveness of a Newly Designed Orthosis on Knee Contact Forces in Subjects With Knee Osteoarthritis, Ortopedia Traumatologia Rehabilitacja (2015)
47. Predictors of Persistent Postsurgical Pain Following Total Knee Arthroplasty: A Protocol for Systematic Review and Meta-Analysis, Canadian Journal of Pain (2019)
48. Evaluation of the Effects of 980 and 810‑Nm High‑Level Diode Lasers in Treating Dentin Hypersensitivity: A Double‑Blinded Randomized Clinical Trial, Dental Research Journal (2022)
49. Clinical Outcomes of Low-Level Laser Therapy in Management of Advanced Implant Surgery Complications: A Comparative Clinical Study, Journal of Contemporary Dental Practice (2019)
50. Osteoarthritis Patients' Experiences of Pharmacotherapy for Pain Management in Iran: A Qualitative Study, Drug Research (2017)