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Effect of Swimming on Oligodendrocytic Cells and Myelin Tissue in Corpus Callosum of Rat Model of Ms Induced by Cuprizone Publisher



Bagheri E1 ; Marandi SM1 ; Ghasemi N2 ; Rezaee Z1
Authors
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Authors Affiliations
  1. 1. Department of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran
  2. 2. Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Medical Journal of Tabriz University of Medical Sciences Published:2021


Abstract

Background: Multiple Sclerosis is a myelin destroyer disease, which physical activity can be effective in improving it. Therefore, in the present study, the effect of swimming on oligodendrocytic cells and myelin tissue in rat brain of the Cuprizone model of MS disease is investigated. Methods: In this study, 21 male Wistar rats were randomly divided into Control groups, Cuprizone and Swim + Cuprizone. For the induction of MS, Cuprizone 0.6% were gavaged for one month. The group of Swim + Cuprizone swam at the same time with gavage. The training program included 4 weeks of swimming for 5 sessions per week and 30 minutes. Immunohistochemistry technique was used to determine the percentage of immature and mature oligodendrocytes and Luxol fast blue solution for evaluation of myelin density. Image j software and One-way ANOVA was used to analyze the findings. Results: The mean percentage of immature and mature oligodendrocytes and myelin density in the Swim+Cuprizone group was significantly higher than that of the Cuprizone group (p≤0.05). Conclusion: Swimming decreases destruction of the oligodendrocytes and myelin cells due to Cuprizone. © 2020 The Author.
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