In Vitro Evaluation of Griseofulvin Against Clinical Isolates of Dermatophytes From Isfahan Publisher Pubmed



Chadeganipour M¹ ; Nilipour S¹ ; Havaei A¹ Show Affiliations
Source: Mycoses Published:2004

Abstract

Fifty dermatophyte isolates, recently obtained from clinical materials, belonging to Trichophyton mentagrophytes, T. verrucosum, Microsporum canis and Epidermophyton floccosum were examined for their susceptibility to griseofulvin. The minimum inhibitory concentration (MIC) values were obtained using the modified microdilution method. All 100% tested isolates had MIC geometric mean at a concentration between 0.43 and 0.95 μg ml-1 The MIC- 90s and MIC50s were 8 μg ml-1 and <0.25-1 μg ml-1 respectively. From all isolates, 12% including three T. verrucosum, one M. canis and two T. mentagrophytes isolates had MIC values out of the standardized range, therefore, they were considered as relatively griseofulvin-resistant. At least some of the isolates tested might be difficult to eradicate in clinical terms with griseofulvin treatment in Isfahan.