Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Lomustine Loaded Superparamagnetic Iron Oxide Nanoparticles Conjugated With Folic Acid for Treatment of Glioblastoma Multiforma (Gbm) Publisher



Jafari S1, 2 ; Tavakoli MB2 ; Zarrabi A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Radiology, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey

Source: Iranian Journal of Pharmaceutical Research Published:2020


Abstract

This study aimed to improve delivery of lomustine as a chemotherapeutic agent and to increase its uptake by U87-MG cancer cells via synthesizes LN-FA-PG-SPIONs (lomustine loaded polyglycerol coated superparamagnetic iron oxide nanoparticles conjugated with folic acid). Nanoparticles were synthesized by thermal decomposition method and characterized using TEM (transmission microscope), FTIR (Fourier transform infrared spectroscopy), and VSM (vibrating sample magnetometer). Lomustine release from nanoparticles was determined by dialysis-bag diffusion technique. Nanoparticles cytotoxicity was evaluated by MTT assay. Mean size of SPIONs and FA-PG-SPIONs (PG-SPIONs conjugated with folic acid) were 7.1 ± 1.13 nm and 25.1 ± 3.94 nm, respectively. Based on FTIR spectra SPIONs were successfully coated by polyglycerol and conjugated with folic acid. Lomustine encapsulation efficiency was 46 ± 6.8 %. SPIONs were cytotoxic on U87-MG cells at concentration above 100 ug/ml (p < 0.05) but PG-SPIONs do not reduce viability significantly (p >0.05). Conjugation of folic acid with PG-SPIONs increased nanoparticles uptake by U87-MG cells (p < 0.05). We concluded that however FA-PG-SPIONs are proposed as a useful tracer for diagnostic and treatment of GBM but their drug delivery properties for lomustine is not satisfactory and more researches are necessary with this regard. © 2020, Iranian Journal of Pharmaceutical Research. All rights reserved.
Related Docs
View other Related Docs
1. Investigation of Combination Effect Between 6 Mv X-Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U87-Mg Cancer Cells, Journal of Biomedical Physics and Engineering (2020)
2. Could Fa-Pg-Spions Act As a Hyperthermia Sensitizing Agent? an in Vitro Study, Journal of Thermal Biology (2018)
3. Synergistic Effect of the Combination of Triethylene-Glycol Modified Fe3o4 Nanoparticles and Ultrasound Wave on Mcf-7 Cells, Journal of Magnetism and Magnetic Materials (2015)
4. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
5. The Role of Folic Acid-Conjugated Polyglycerol Coated Iron Oxide Nanoparticles on Radiosensitivity With Clinical Electron Beam (6 Mev) on Human Cervical Carcinoma Cell Line: In Vitro Study, Journal of Photochemistry and Photobiology B: Biology (2018)
6. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
7. Preparation and Cytotoxic Evaluation of Magnetite (Fe3o4) Nanoparticleon Breast Cancer Cells and Its Combinatory Effects With Doxorubicin Used in Hyperthermia, Avicenna Journal of Medical Biotechnology (2013)
8. Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded With Doxorubicin on Mcf-7 Cells, Journal of Isfahan Medical School (2013)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (47)
Farshid Hassanzadeh (26)
Other Related Docs
9. Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer, Pharmaceutical Development and Technology (2017)
10. Doxorubicin Hydrochloride - Loaded Electrospun Chitosan/Cobalt Ferrite/Titanium Oxide Nanofibers for Hyperthermic Tumor Cell Treatment and Controlled Drug Release, International Journal of Biological Macromolecules (2018)
11. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
12. Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and in Vitro Cytotoxicity Evaluations, Langmuir (2021)
13. Evaluation of Rs1957106 Polymorphism of Nf-Κbi in Glioblastoma Multiforme in Isfahan, Iran, Advanced Biomedical Research (2019)
14. In Vitro and in Vivo Evaluation of Novel Dtx-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes, Recent Patents on Anti-Cancer Drug Discovery (2020)
15. Incorporation of Magnetic Nax Zeolite/Dox Into the Pla/Chitosan Nanofibers for Sustained Release of Doxorubicin Against Carcinoma Cells Death in Vitro, International Journal of Biological Macromolecules (2019)
16. Porphyrin–Iron Oxide Nanoparticle Functionalized With Trastuzumab (Ion–Pp–Tz) Potential Mr Imaging Probe for Breast Cancer Cells, Applied Physics A: Materials Science and Processing (2022)
17. Boron Phenyl Alanine Targeted Ionic Liquid Decorated Chitosan Nanoparticles for Mitoxantrone Delivery to Glioma Cell Line, Pharmaceutical Development and Technology (2021)
18. Investigating the Effectiveness of 6 Mev Electron and Ultrasound Beams With the Use of Iron Oxide Magnetic Nanoparticles Attached to Cisplatin on B16f10 Cells: In-Vitro Study, International Journal of Nanoscience (2024)
19. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma, BioMed Research International (2015)
20. Functionalized Graphene Oxide/Fe3o4 Nanocomposite: A Biocompatible and Robust Nanocarrier for Targeted Delivery and Release of Anticancer Agents, Journal of Biotechnology (2021)
21. Iron Oxyhydroxide Nanoparticles: Green Synthesis and Their Cytotoxicity Activity Against A549 Human Lung Adenocarcinoma Cells, Rendiconti Lincei (2022)
22. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
23. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
24. Recent Progress in Cancer Immunotherapy: Application of Nano-Therapeutic Systems, Journal of Drug Delivery Science and Technology (2024)
25. Feasibility of Haloperidol-Anchored Albumin Nanoparticles Loaded With Doxorubicin As Dry Powder Inhaler for Pulmonary Delivery, Pharmaceutical Development and Technology (2015)
26. Chondroitin/Doxorubicin Nanoparticulate Polyelectrolyte Complex for Targeted Delivery to Hepg2 Cells, IET Nanobiotechnology (2017)
27. Poly(Glycerol Sebacate) Nanoparticles for Ocular Delivery of Sunitinib: Physicochemical, Cytotoxic and Allergic Studies, IET Nanobiotechnology (2019)
28. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
29. Development and Optimization of Transferrin-Conjugated Nanostructured Lipid Carriers for Brain Delivery of Paclitaxel Using Box–Behnken Design, Pharmaceutical Development and Technology (2017)
30. Physicochemical, Pharmacodynamic and Pharmacokinetic Characterization of Soluplus Stabilized Nanosuspension of Tacrolimus, Current Drug Delivery (2017)
31. Boron Phenyl Alanine Targeted Chitosan–Pnipaam Core–Shell Thermo-Responsive Nanoparticles: Boosting Drug Delivery to Glioblastoma in Bnct, Drug Development and Industrial Pharmacy (2021)
32. Ag-Zno Nanoparticles: Synthesis, Characterization, Antibacterial Activity on S. Mutans, Along With Cytotoxic Effect on U87 Cell Line, Nanomedicine Research Journal (2022)
33. An Injectable Thermosensitive Hydrogel/Nanomicelles Composite for Local Chemo-Immunotherapy in Mouse Model of Melanoma, Journal of Biomaterials Applications (2022)
34. Pegylated Multifunctional Ph-Responsive Targeted Polymeric Micelles for Ovarian Cancer Therapy: Synthesis, Characterization and Pharmacokinetic Study, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
35. Evaluation of Lipid Nanocarriers in the Form of Sln and Their Application in Drug Delivery, Nanochemistry Research (2023)
36. Synthesis and Characterization of Folate-Targeted Dextran/Retinoic Acid Micelles for Doxorubicin Delivery in Acute Leukemia, BioMed Research International (2014)
37. Biosynthesis of Lead Oxide and Cerium Oxide Nanoparticles and Their Cytotoxic Activities Against Colon Cancer Cell Line, Inorganic Chemistry Communications (2021)
38. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)
39. 5Fu-Loaded Pcl/Chitosan/Fe3o4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System, Advanced Pharmaceutical Bulletin (2022)
40. Use of Magnetic Folate-Dextran-Retinoic Acid Micelles for Dual Targeting of Doxorubicin in Breast Cancer, BioMed Research International (2013)
41. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
42. Hydroxypyridinone Derivatives: Synthesis and Cytotoxic Evaluation, Journal of Reports in Pharmaceutical Sciences (2013)
43. Cytotoxic Effects of Targeted Galactosylated Pluronic F127/Pluronicl122 Nano-Sized Micelles Loaded With Doxorubicin in Human Hepatocellular Carcinoma Cell Line, Journal of Isfahan Medical School (2013)
44. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
45. Evaluation of Thermosensitive Chitosan Hydrogel Containing Gefitinib Loaded Cellulose Acetate Butyrate Nanoparticles in a Subcutaneous Breast Cancer Model, International Journal of Pharmaceutics (2022)
46. The Therapeutic Effect of Combination of X-Ray and Iron Oxide Nanoparticles Attached to Dacarbazine Chemotherapy Drug on Melanoma Cell Line, Journal of Isfahan Medical School (2022)
47. Superparamagnetic Iron Oxide Nanoparticle-Loaded Nanodroplets for Dual-Modal Ultrasound/Magnetic Resonance Imaging-Guided Drug Delivery, New Journal of Chemistry (2023)
48. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
49. Fluorescence Resonance Energy Transfer Monitoring of Ph-Responsive Doxorubicin Release From Carbon Dots/Aptamer Functionalized Magnetic Mesoporous Silica, Nanomedicine (2021)
50. Biosynthesis of Core–Shell Α-Fe2o3@Au Nanotruffles and Their Biomedical Applications, Biomass Conversion and Biorefinery (2024)