Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients?

Isfahan University of Medical Sciences

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Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients? Publisher Pubmed

Farahmand S¹ ; Ahmadi O² ; Dehpour A³ ; Khashayar P⁴

Show Affiliations

1. Department of Emergency Medicine, Imam - Khomeini Hospital, Tehran University of Medical Sciences, Tehran, 1419733141, Iran
2. Department of Emergency Medicine, Esfahan University of Medical Sciences, Esfahan, 8174675731, Iran
3. Department of Pharmacology, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
4. Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, 14114, Iran

Source: American Journal of Emergency Medicine Published:2012

Abstract

Objective: The present study aims to assess the influence of ultra-low doses of opioid antagonists on the analgesic properties of opioids and their side effects. Methods: In the present randomized, double-blind controlled trial, the influence of the combination of ultra-low-dose naltrexone and morphine on the total opioid requirement and the frequency of the subsequent side effects was compared with that of morphine alone (added with placebo) in patients with trauma in the upper or lower extremities. Results: Although the morphine and naltrexone group required 0.04 mg more opioids during the study period, there was no significant difference between the opioid requirements of the 2 groups. Nausea was less frequently reported in patients receiving morphine and naltrexone. Conclusion: The combination of ultra-low-dose naltrexone and morphine in extremity trauma does not affect the opioid requirements; it, however, lowers the risk of nausea. © 2012 Elsevier Inc. All rights reserved.

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Style	Citing Format
MLA	Farahmand S, et al.. "Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients?." American Journal of Emergency Medicine, vol. 30, no. 1, 2012, pp. 75-78.
APA	Farahmand S, Ahmadi O, Dehpour A, Khashayar P (2012). Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients?. American Journal of Emergency Medicine, 30(1), 75-78.
Chicago	Farahmand S, Ahmadi O, Dehpour A, Khashayar P. "Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients?." American Journal of Emergency Medicine 30, no. 1 (2012): 75-78.
Harvard	Farahmand S et al. (2012) 'Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients?', American Journal of Emergency Medicine, 30(1), pp. 75-78.
Vancouver	Farahmand S, Ahmadi O, Dehpour A, Khashayar P. Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients?. American Journal of Emergency Medicine. 2012;30(1):75-78.
BibTex	@article{ author = {Farahmand S and Ahmadi O and Dehpour A and Khashayar P}, title = {Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients?}, journal = {American Journal of Emergency Medicine}, volume = {30}, number = {1}, pages = {75-78}, year = {2012} }
RIS	TY - JOUR AU - Farahmand S AU - Ahmadi O AU - Dehpour A AU - Khashayar P TI - Does Adding Low Doses of Oral Naltrexone to Morphine Alter the Subsequent Opioid Requirements and Side Effects in Trauma Patients? JO - American Journal of Emergency Medicine VL - 30 IS - 1 SP - 75 EP - 78 PY - 2012 ER -