E-Cadherin Expression As a Prognostic Factor in Transitional Cell Carcinoma of the Bladder After Transurethral Resection Pubmed



Khorrami MH¹ ; Hadi M¹ ; Gharaati MR¹ ; Izadpanahi MH¹ ; Javid A¹ ; Zargham M¹ Show Affiliations
Source: Urology Journal Published:2012

Abstract

Purpose: To analyze the role of negative versus positive immunoexpression of E-cadherin in recurrence rate of low-grade bladder tumors. Materials and Methods: A total of 180 patients with unifocal, superficial, low-grade, papillary transitional cell carcinoma of the bladder were included in this study. The E-cadherin expression was evaluated using E-cadherin antibody. The patients were followed up for 36 months. Thereafter, recurrence rate of the tumor was compared between E-cadherin positive and negative groups. Results: Of 180 low-grade carcinomas, E-cadherin immunoexpression was negative in 101 (56%) and positive in 79 (44%) patients. The recurrence rate in negative and positive groups was 65.6% and 37.9%, respectively. Negative in comparison with positive E-cadherin expression was associated with more disease recurrence (P =.045). Conclusion: There is an association between decreased E-Cadherin immunoexpression and tumor recurrence in low-grade and non-muscle invasive transitional cell carcinoma of the bladder.