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Effect of Melatonin in the Prevention of Post-Operative Adhesion Formation in an Experimental Study



Movahedi M1 ; Hajhashemy M1 ; Adibi S2
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Authors Affiliations
  1. 1. School of Medicine, Isfahan University of Medical Sciences, Iran
  2. 2. Torabi Nejad Research center, Isfahan University of Medical Sciences, Iran

Source: Journal of Isfahan Medical School Published:2007

Abstract

Post operative adhesion formation is a very important clinical problem because of its complications such as pain, bowel obstruction, infertility and subsequent intra-operative complications. We aimed to investigate the effects of melatonin (ME), as an agent acting against free radicals, on the prevention of adhesion formation. Background: A number of 39 rats were randomly assigned into three groups of equal number. Serosal injury was created using a standard technique, one group received a single dose of intraperitoneal (IP) ME immediately after injury; a single dose of subcutaneous (SC) ME was given to the second group 30 minutes prior to surgery; but the control group did not received ME. All animals were re-operated 2 weeks after the surgery and the adhesion scores were determined by an examiner blinded to the under experiment groups. Methods: The total score of adhesion reduced significantly in IP and SC groups in comparison to controls (p). © 2007, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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