Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside

Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside Publisher Pubmed

Rafieemehr H¹ ; Samimi A² ; Maleki Behzad M³ ; Ghanavat M⁴ ; Shahrabi S⁵

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1. Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
2. Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5. Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Source: Clinical and Translational Oncology Published:2020

Abstract

Leukemic cells’ (LCs) survival, proliferation, activation, differentiation, and invasiveness/migration can be mediated through the function of cation and anion channels that are involved in volume regulation, polarization, cytoskeleton, and extracellular matrix reorganization. This study will review the expression of ion channels in LCs and their possible function in leukemia progression. We searched relevant literature by a PubMed (2002–2019) of English-language literature using the terms “ion channels”, “leukemia”, “proliferation”, “differentiation”, “apoptosis”, and “migration”. Altered expression and dysfunction of ion channels can have a strong impact on hematopoietic cell and LCs physiology and signaling, which contributes to the vital processes such as proliferation, differentiation, and apoptosis. Indeed, it can be stated that changing expression of ion channels can affect the onset and progression as well as clinical features and therapeutic responses of leukemia via inducing the maintenance of LCs. Since ion channels are membrane proteins, they can be easily accessible in LCs for understanding their influence on leukemia progression. On the other hand, ion channels can be new potential targets for chemotherapeutic agents, which may open a novel clinical and pharmaceutical field in leukemia therapy. © 2019, Federacion de Sociedades Espanolas de Oncologia (FESEO).

Style	Citing Format
MLA	Rafieemehr H, et al.. "Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside." Clinical and Translational Oncology, vol. 22, no. 3, 2020, pp. 283-293.
APA	Rafieemehr H, Samimi A, Maleki Behzad M, Ghanavat M, Shahrabi S (2020). Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside. Clinical and Translational Oncology, 22(3), 283-293.
Chicago	Rafieemehr H, Samimi A, Maleki Behzad M, Ghanavat M, Shahrabi S. "Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside." Clinical and Translational Oncology 22, no. 3 (2020): 283-293.
Harvard	Rafieemehr H et al. (2020) 'Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside', Clinical and Translational Oncology, 22(3), pp. 283-293.
Vancouver	Rafieemehr H, Samimi A, Maleki Behzad M, Ghanavat M, Shahrabi S. Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside. Clinical and Translational Oncology. 2020;22(3):283-293.
BibTex	@article{ author = {Rafieemehr H and Samimi A and Maleki Behzad M and Ghanavat M and Shahrabi S}, title = {Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside}, journal = {Clinical and Translational Oncology}, volume = {22}, number = {3}, pages = {283-293}, year = {2020} }
RIS	TY - JOUR AU - Rafieemehr H AU - Samimi A AU - Maleki Behzad M AU - Ghanavat M AU - Shahrabi S TI - Altered Expression and Functional Role of Ion Channels in Leukemia: Bench to Bedside JO - Clinical and Translational Oncology VL - 22 IS - 3 SP - 283 EP - 293 PY - 2020 ER -

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