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An Overview of Animal Models Induced by Glucocorticoids Publisher



Mesripour A1 ; Asgharivarzaneh M1 ; Safaeian L1
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Physiology and Pharmacology (Iran) Published:2023


Abstract

Glucocorticoids are widely employed for treating various disorders, but their administration is associated with multiple adverse effects. To study and understand these side effects, pre-clinical animal models have been developed. Experimental models that replicate essential aspects of human diseases offer valuable tools for assessing potential therapeutic agents and elucidating molecular and cellular pathways in a controlled environment. In this review, we provide an overview of various animal models in which glucocorticoids have been utilized to induce humanlike disorders across different body systems. These disorders encompass hypertension, skin atrophy, hair loss, insulin resistance, dyslipidemia, gastric mucosal damage, growth retardation, muscle atrophy, osteoporosis, osteonecrosis, depression-like behavior, glaucoma, and cataracts. © 2023, Iranian Society of Physiology and Pharmacology. All rights reserved.
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