Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates

Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates Pubmed

Zarghi A¹ ; Ebrahimabadi AH² ; Hassanzadeh F² ; Heydari MR³ ; Shafiee A⁴

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1. Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Shaheed Beheshti Univ. of Med. Sci., Tehran, Iran
2. Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Isfahan Univ. of Medical Sciences, Isfahan, Iran
3. Department of Pharmacology, Faculty of Pharmacy, Kerman Univ. of Medical Sciences, Kerman, Iran
4. Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Tehran Univ. of Medical Sciences, Tehran, Iran

Source: Bollettino Chimico Farmaceutico Published:2003

Abstract

A series of 1-methyl-4-(4-X-arylsulfonyl)pyrrolo[2,3-d]imidazole-5-carboxylates were synthesized and tested as anti-inflammatory agents. Indomethacin was used as reference drug. Two of the synthesized compounds 7a and 7b had an effect equal to 0.1 of indomethacin. Our result showed that the electron-withdrawing substituents in the para position of the benzensulfonyl moiety increase activity.

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Style	Citing Format
MLA	Zarghi A, et al.. "Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates." Bollettino Chimico Farmaceutico, vol. 142, no. 6, 2003, pp. 251-254.
APA	Zarghi A, Ebrahimabadi AH, Hassanzadeh F, Heydari MR, Shafiee A (2003). Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates. Bollettino Chimico Farmaceutico, 142(6), 251-254.
Chicago	Zarghi A, Ebrahimabadi AH, Hassanzadeh F, Heydari MR, Shafiee A. "Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates." Bollettino Chimico Farmaceutico 142, no. 6 (2003): 251-254.
Harvard	Zarghi A et al. (2003) 'Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates', Bollettino Chimico Farmaceutico, 142(6), pp. 251-254.
Vancouver	Zarghi A, Ebrahimabadi AH, Hassanzadeh F, Heydari MR, Shafiee A. Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates. Bollettino Chimico Farmaceutico. 2003;142(6):251-254.
BibTex	@article{ author = {Zarghi A and Ebrahimabadi AH and Hassanzadeh F and Heydari MR and Shafiee A}, title = {Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates}, journal = {Bollettino Chimico Farmaceutico}, volume = {142}, number = {6}, pages = {251-254}, year = {2003} }
RIS	TY - JOUR AU - Zarghi A AU - Ebrahimabadi AH AU - Hassanzadeh F AU - Heydari MR AU - Shafiee A TI - Synthesis and Anti-Inflammatory Activity of New 1-Methyl-4-(4-X-Benzenesulfonyl)Pyrrolo[2,3-D] Imidazole-5-Carboxylates JO - Bollettino Chimico Farmaceutico VL - 142 IS - 6 SP - 251 EP - 254 PY - 2003 ER -

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