Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production

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Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production Publisher Pubmed

Gharagozloo M¹ ; Velardi E² ; Bruscoli S² ; Agostini M² ; Di Sante M² ; Donato V² ; Amirghofran Z³ ; Riccardi C²

Source: Pharmacological Research Published:2010

Abstract

Silymarin, a mixture of bioactive flavonolignans isolated from Silybum marianum, exhibits anti-carcinogenic, anti-inflammatory and cytoprotective effects. In this study, the in vitro immunomodulatory activity of silymarin was investigated using CD4+ splenocytes from C57/Bl6 mice. Proliferation assay revealed that silymarin, at 50. μM concentration, significantly inhibited CD4+ cells proliferation. ELISA analyses indicated that silymarin significantly inhibited IL-2 and IFN-γ production. Immunofluorescence staining performed on the mouse hybridoma T cell line (3DO) revealed a block of nuclear translocation of transcription factor κB (NF-κB), which is known to be responsible for IL-2 transcriptional activation. Moreover, silymarin inhibited p65/NF-κB phosphorylation in CD4+ T cell. These results suggest that silymarin is able to inhibit T cell activation and proliferation, notably acting on pathways of NF-κB activation/translocation. © 2010 Elsevier Ltd.

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Style	Citing Format
MLA	Gharagozloo M, et al.. "Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production." Pharmacological Research, vol. 61, no. 5, 2010, pp. 405-409.
APA	Gharagozloo M, Velardi E, Bruscoli S, Agostini M, Di Sante M, Donato V, Amirghofran Z, Riccardi C (2010). Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production. Pharmacological Research, 61(5), 405-409.
Chicago	Gharagozloo M, Velardi E, Bruscoli S, Agostini M, Di Sante M, Donato V, Amirghofran Z, Riccardi C. "Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production." Pharmacological Research 61, no. 5 (2010): 405-409.
Harvard	Gharagozloo M et al. (2010) 'Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production', Pharmacological Research, 61(5), pp. 405-409.
Vancouver	Gharagozloo M, Velardi E, Bruscoli S, Agostini M, Di Sante M, Donato V, et al.. Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production. Pharmacological Research. 2010;61(5):405-409.
BibTex	@article{ author = {Gharagozloo M and Velardi E and Bruscoli S and Agostini M and Di Sante M and Donato V and Amirghofran Z and Riccardi C}, title = {Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production}, journal = {Pharmacological Research}, volume = {61}, number = {5}, pages = {405-409}, year = {2010} }
RIS	TY - JOUR AU - Gharagozloo M AU - Velardi E AU - Bruscoli S AU - Agostini M AU - Di Sante M AU - Donato V AU - Amirghofran Z AU - Riccardi C TI - Silymarin Suppress Cd4+ T Cell Activation and Proliferation: Effects on Nf-Κb Activity and Il-2 Production JO - Pharmacological Research VL - 61 IS - 5 SP - 405 EP - 409 PY - 2010 ER -

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