Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Signs of the Presence of Th17 Cells in Chronic Periodontal Disease Publisher Pubmed



Adibrad M1 ; Deyhimi P2 ; Ganjalikhani Hakemi M3 ; Behfarnia P1 ; Shahabuei M1 ; Rafiee L4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Departments of Periodontology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Departments of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Applied Physiology Research Center, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Periodontal Research Published:2012


Abstract

Background and Objective: The aim of this study was to identify the specific markers of T helper 17 (Th17) cells and their variations in people suffering from chronic periodontal disease in comparison with normal control subjects. Material and Methods: In 30 patients with periodontitis and 30 normal control subjects, the mRNA expressions of interleukin (IL)-17A and retinoic orphan receptorC2 (RORC2) were measured by quantitative RT-PCR. The protein levels of IL-17A and RORC2 were also evaluated by immunohistochemistry. The levels of these markers were compared between healthy and diseased periodontal tissues by the Mann-Whitney U-test. Results: In periodontal lesions, IL-17A and RORC2 were significantly overexpressed compared with normal tissues. According to our immunohistochemical analysis, the number of IL-17A-positive cells and RORC2-positive cells was significantly greater in periodontal lesions compared with control sites. Moreover, there was a positive correlation between the presence of IL-17A and RORC2 transcript and protein content levels in the gingiva of diseased patients. Conclusion: The results demonstrated a significant increase in the number of some specific markers of Th17 cells in patients suffering from periodontal disease in comparison with normal control subjects. © 2012 John Wiley & Sons A/S.
Related Docs
View other Related Docs
1. Optimization of Human Th17 Cell Differentiation in Vitro: Evaluating Different Polarizing Factors, In Vitro Cellular and Developmental Biology - Animal (2011)
2. Positive and Negative Regulation of Th17 Cell Differentiation: Evaluating the Impact of Rorc2, Cell Journal (2014)
3. Il29 Expression in Gingival Tissues of Chronic Periodontitis and Aggressive Periodontitis Patients: An Immunohistochemical Analysis, Dental Research Journal (2021)
4. Interleukin-35 Pathobiology in Periodontal Disease: A Systematic Scoping Review, BMC Oral Health (2021)
5. Evaluation of Il-17 Gene Expression in Peripheral Blood and Sputum of Asthma Patients and Healthy Individuals, Tehran University Medical Journal (2014)
6. Mir-326 and Mir-26A, Two Potential Markers for Diagnosis of Relapse and Remission Phases in Patient With Relapsing-Remitting Multiple Sclerosis, Gene (2014)
7. C-Reactive Protein Levels in Chronic Gingivitis, Chronic Periodontitis and Periodontally Healthy Subjects, HealthMED (2012)
8. Association of A-197G Polymorphism in Interleukin-17 Gene With Chronic Periodontitis: Evidence From Six Case-Control Studies With a Computational Biology Approach, Journal of investigative and clinical dentistry (2019)
Experts (# of related papers)
View all Related Experts
Mazdak Ganjalikhani Hakemi (9)
Mohsen Hosseini (5)
Other Related Docs
9. Assessment of Microrna-146A in Generalized Aggressive Periodontitis and Its Association With Disease Severity, Journal of Periodontal Research (2019)
10. Cytokine Gene Expression in Newly Diagnosed Multiple Sclerosis Patients, Iranian Journal of Allergy, Asthma and Immunology (2015)
11. Comparative Immune Response in Children and Adults With H. Pylori Infection, Journal of Immunology Research (2015)
12. Evaluation of Th17 Immune Responses of Recombinant Dna Vaccine Encoding Gra14 and Rop13 Genes Against Toxoplasma Gondii in Balb/C Mice, Infection, Genetics and Evolution (2021)
13. Meta-Analysis of Risk Association Between Interleukin-17A and F Gene Polymorphisms and Inflammatory Diseases, Journal of Interferon and Cytokine Research (2017)
14. Is Periodontitis Associated With the Risk of Immune-Mediated Systemic Conditions?, Evidence-Based Dentistry (2023)
15. Exosomes Derived From Mesenchymal Stem Cells: Heralding a New Treatment for Periodontitis?, Tissue and Cell (2023)
16. Effects of Ginseng Supplementation on Selected Markers of Inflammation: A Systematic Review and Meta-Analysis, Phytotherapy Research (2019)
17. Antibacterial Activity of Curcumin Against Periodontal Pathogens: A Systematic Review, Advances in Experimental Medicine and Biology (2021)
18. The -592C>A Variation of Il-10 Gene and Susceptibility to Chronic Periodontitis: A Genetic Association Study and In-Silico Analysis, Journal of Oral Biosciences (2021)
19. Evaluation of the T Helper 17 Cell Specific Genes and the Innate Lymphoid Cells Counts in the Peripheral Blood of Patients With the Common Variable Immunodeficiency, Journal of Research in Medical Sciences (2014)
20. Study on Gene Expression of Il-17A in Eutopic and Ectopic Tissue Sample of Endometriosis Patients and Comparison With Control Group, Biomedical Research and Therapy (2024)
21. Evaluation of Il-17 Gene Expression in the Peripheral Blood of Patients With Common Variable Immunodeficiency, Journal of Isfahan Medical School (2013)
22. Association Between Periodontal Disease and Non-Apnea Sleep Disorder: A Systematic Review, Clinical Oral Investigations (2020)
23. R0rc2 Gene Silencing in Human Th17 Cells by Sirna: Design and Evaluation of Highly Efficient Sirna, Avicenna Journal of Medical Biotechnology (2013)
24. Evaluating the Effects of Epigallocatechin-3-Gallate on Hif-1Α Protein and Rorc Gene Expression in Peripheral Blood Mononuclear Cells in Patients With Multiple Sclerosis, Basic and Clinical Neuroscience (2021)
25. Association Between Periodontitis and Alzheimer's Disease: A Narrative Review, IBRO Neuroscience Reports (2025)
26. The Effect of Vitamin E Supplementation on Treatment of Chronic Periodontitis, Dental Research Journal (2021)
27. Functional Analysis of Two Stat1 Gain-Of-Function Mutations in Two Iranian Families With Autosomal Dominant Chronic Mucocutaneous Candidiasis, Medical Mycology (2021)
28. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
29. Salivary Concentration of Tnfα, Il1α, Il6, and Il8 in Oral Squamous Cell Carcinoma, Medicina Oral, Patologia Oral y Cirugia Bucal (2008)
30. New Insight to Il-23/Il-17 Axis in Iranian Infected Adult Patients With Gastritis : Effects of Genes Polymorphisms on Expression of Cytokines, Acta Gastro-Enterologica Belgica (2015)
31. Amelioration for an Ignored Pitfall in Reference Gene Selection by Considering the Mean Expression and Standard Deviation of Target Genes, Scientific Reports (2022)
32. Association of Periodontitis and Aging-Related Diseases: A Review of Mechanistic Studies, Journal of Research in Dental and Maxillofacial Sciences (2023)
33. Interleukin - 17 and Interleukin-10 As Inflammatory and Prevention Biomarkers in Periimplant Diseases, International Journal of Preventive Medicine (2019)
34. Evaluation of the Associations Between Dry Mouth, Oral Lesions, and Orofacial Pain With Covid-19: A Systematic Review and Meta-Analysis, Journal of Pharmaceutical Negative Results (2022)
35. Modulation of Th17 Proliferation and Il-17A Gene Expression by Acetylated Form of Apigenin in Patients With Multiple Sclerosis, Immunological Investigations (2021)
36. Pro-Inflammatory Cytokines May Associate Periodontitis With Pregnancy Complications: A Short Review, New Emirates Medical Journal (2024)
37. Prevalence of Porphyromonas Gingivalis and Bacteroides Forsythus in Chronic Periodontitis by Multiplex Pcr, Pakistan Journal of Biological Sciences (2007)
38. Visfatin Expression in Gingival Tissues of Chronic Periodontitis and Aggressive Periodontitis Patients: An Immunohistochemical Analysis, Dental Research Journal (2018)
39. Periodontitis and Cardiovascular Disease: A Literature Review, ARYA Atherosclerosis (2021)