Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Development and Characterization of Buccoadhesive Nifedipine Tablets Publisher Pubmed



Varshosaz J1 ; Dehghan Z2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy and Phamaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmaceutics, School of Pharmacy and Phamaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, P.O. Box 81745-359, Iran

Source: European Journal of Pharmaceutics and Biopharmaceutics Published:2002


Abstract

The buccoadhesive controlled-release tablets for delivery of nifedipine were prepared by direct compression of carboxymethyl cellulose (CMC) with carbomer (CP), which showed superior bioadhesion properties compared to polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), hydroxypropylmethyl cellulose (HPMC), and acacia in a modified tensiometry method in vitro. The tablets containing 30mg of nifedipine and various amounts of CMC and CP showed a zero-order drug release kinetic. The adhesion force was significantly affected by the mixing ratio of CP:CMC in the tablets. The weakest and highest adhesion force was observed at the mixing ratios of 1:0 and 8:2 of CP:CMC, respectively. The tablets containing 15% CMC and 35% CP adhered for over 8h to the upper gums of six healthy human volunteers. These tablets released about 56% of the loaded drug after 8h in vivo with a rate of 2.17h-1 and were perfectly tolerated, while they released about 100% of their content after the same time with a rate of 3.49h-1 in vitro. A good correlation (r2=0.989) was observed between drug-released in vitro and in vivo. Copyright © 2002 Elsevier Science B.V.
Related Docs
View other Related Docs
1. Development and Evaluation of Controlled-Release Buccoadhesive Verapamil Hydrochloride Tablets, Daru (2008)
2. Preparation and Characterization of a Sustained Release Buccoadhesive System for Delivery of Terbutaline Sulfate, Research in Pharmaceutical Sciences (2013)
3. Pharmaceutical Evaluation of Ziziphus Jujuba Mucoadhesive Buccal Film, Journal of Reports in Pharmaceutical Sciences (2015)
4. Preparation and Pharmaceutical Evaluation of Glibenclamide Slow Release Mucoadhesive Buccal Film, Research in Pharmaceutical Sciences (2014)
5. Formulation and in Vitro Characterization of Ciprofloxacin Floating and Bioadhesive Extended-Release Tablets, Drug Delivery (2006)
6. Formulation and Evaluation of Triamcinolone Acetonide Mucoadhesive Film As Treatment of Aphthous Stomatitis and Oral Inflammatory Diseases, Journal of Isfahan Medical School (2013)
7. Development and Physical Characterization of a Periodontal Bioadhesive Gel of Metronidazole, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2002)
8. Formulation and Evaluation of Phenytoin Sodium Buccoadhesive Polymeric Film for Oral Wounds, Iranian Journal of Pharmaceutical Sciences (2011)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (27)
Jaber Emami Baferani (8)
Other Related Docs
9. Preparation and Physicochemical Evaluation of Nystatine Mucoadhesive Buccal Film, Journal of Reports in Pharmaceutical Sciences (2013)
10. Preparation and Pharmaceuticals Evaluation of Nicotine Muccoadhesive Tablet for Smoking Cessation, Pharmaceutical Sciences (2012)
11. Preparation and Evaluation of a New Salbutamol Fast-Dissolving Oral Film for Asthma Treatment, Journal of Isfahan Medical School (2013)
12. Development of Novel Budesonide Pellets Based on Codes™ Technology: In Vitro/In Vivo Evaluation in Induced Colitis in Rats, DARU, Journal of Pharmaceutical Sciences (2011)
13. Development and Evaluation of Wafer Loaded With Sertaconazole Solid Dispersion for the Treatment of Oral Candidiasis, Brazilian Journal of Pharmaceutical Sciences (2023)
14. Evaluation of Trigonella Foenum-Graecum Seeds Gum As a Novel Tablet Binder, International Journal of Pharmacy and Pharmaceutical Sciences (2012)
15. Preparation and Characterization of a Hydroxypropyl Methylcellulose Based Wafer for Simultaneous Delivery of Phenytoin and Insulin As Wound Dressing Material, Pharmaceutical Development and Technology (2022)
16. Use of Enteric Polymers for Production of Microspheres by Extrusion-Spheronization, Pharmaceutica Acta Helvetiae (1997)
17. Evaluation of Release Kinetics and Mechanisms of Curcumin and Curcumin-Β-Cyclodextrin Inclusion Complex Incorporated in Electrospun Almond Gum/Pva Nanofibers in Simulated Saliva and Simulated Gastrointestinal Conditions, BioNanoScience (2019)
18. Preparation and Characterization of Solid Dispersions of Celecoxib Obtained by Spray-Drying Ethanolic Suspensions Containing Pvp-K30 or Isomalt, Journal of Drug Delivery Science and Technology (2018)
19. Formulation, Optimization and in Vitro Evaluation of Rapid Disintegrating and Mucoadhesive Sublingual Tablets of Lorazepam, Farmacia (2015)
20. Enhancement of Dissolution Rate of Fenofibrate by Spray Drying Technique: Comparison of Eudragit E-100, Solutol® Hs15 and Hydroxypropyl Cellulose As Carriers, Farmacia (2015)
21. Effects of Concentration, Temperature and Polymer Type on Drug Release From Montmorillonite-Donepezil Nanocomposites, Journal of Isfahan Medical School (2013)
22. Development of Bioadhesive Chitosan Gels for Topical Delivery of Lidocaine, Scientia Pharmaceutica (2006)
23. Active Packaging Films Made by Complex Coacervation of Tragacanth Gum and Gelatin Loaded With Curcumin; Characterization and Antioxidant Activity, Foods (2022)
24. Use of Natural Gums and Cellulose Derivatives in Production of Sustained Release Metoprolol Tablets, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
25. Medicated Chewing Gum, a Novel Drug Delivery System, Journal of Research in Medical Sciences (2015)
26. Polyelectrolyte Complexes of Chitosan for Production of Sustained Release Tablets of Bupropion Hcl, Farmacia (2015)
27. Development of Bioadhesive Chitosan Gels for Topical Delivery of Lidocaine, Journal of Isfahan Medical School (2012)
28. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
29. Enhancement of Solubility and Antidiabetic Effects of Repaglinide Using Spray Drying Technique in Stz-Induced Diabetic Rats, Pharmaceutical Development and Technology (2017)
30. Influence of Different Solid-Dispersion Techniques Upon the Release of Dimenhydrinate From Chewing-Gum Formulations, Scientia Pharmaceutica (2002)
31. Preparation and Evaluation of Theophylline Sustained Release Microcapsules Using Coacervation, Journal of Dispersion Science and Technology (2012)
32. Novel Lectin-Modified Poly(Ethylene-Co-Vinyl Acetate) Mucoadhesive Nanoparticles of Carvedilol: Preparation and in Vitro Optimization Using a Two-Level Factorial Design, Pharmaceutical Development and Technology (2014)
33. Gastric Floating Matrix Tablets of Metformin Hcl: Design and Optimization Using Combination of Polymers, Journal of Reports in Pharmaceutical Sciences (2016)
34. Use of Hydrophilic Natural Gums in Formulation of Sustained-Release Matrix Tablets of Tramadol Hydrochloride, AAPS PharmSciTech (2006)
35. Optimization and Comparison of Unidirectional Lidocaine-Loaded Buccal Patch With the Articaine-Loaded Buccal Patch to Reduce Injection Pain and Increment of Patients' Compliance in Dental Procedures: A Double‐Blind Randomized Controlled Trial, Heliyon (2024)
36. Enhancement of Anti-Diabetic Effects of Gliclazide Using Immediate Release Tablets in Streptozotocin-Induced Diabetic and Normal Rats, Farmacia (2013)
37. Preparation and in Vitro Evaluation of Sustained-Release Matrix Tablets of Flutamide Using Synthetic and Naturally Occurring Polymers, Iranian Journal of Pharmaceutical Research (2008)
38. Influence of Β - Cyclodextrin Complexation on Lovastatin Release From Osmotic Pump Tablets (Opt), Daru (2007)
39. Cross-Linked Poly (Vinyl Alcohol) Hydrogel: Study of Swelling and Drug Release Behaviour, Iranian Polymer Journal (English Edition) (2002)
40. Formulation of Sustained - Release Lithium Carbonate Matrix Tablets: Influence of Hydrophilic Materials on the Release Rate and in Vitro-In Vivo Evaluation, Journal of Pharmacy and Pharmaceutical Sciences (2004)
41. Colon Specific Delivery of Budesonide Based on Triple Coated Pellets: In Vitro/In Vivo Evaluation, Acta Pharmaceutica (2012)
42. Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System, Drug Development and Industrial Pharmacy (2007)
43. Preparation and Pharmaceutical Evaluation of Miconazole Nitrate Mucoadhesive Films for Vaginal Candidiasis, Journal of Isfahan Medical School (2013)
44. Preparation, Characterization and Optimization of Glipizide Controlled Release Nanoparticles, Research in Pharmaceutical Sciences (2014)
45. Thermal Treating of Acrylic Matrices As a Tool for Controlling Drug Release, Chemical and Pharmaceutical Bulletin (2009)
46. Cytotoxicity of Orthodontic Bonding Adhesive Resins on Human Oral Fibroblasts, European Journal of Orthodontics (2010)
47. Preparation and Characterization of Metoprolol Controlled-Release Solid Dispersions, Drug Delivery (2006)
48. Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design, Journal of Nanomaterials (2012)
49. Simvastatin Nanosuspensions Prepared Using a Combination of Ph-Sensitive and Timed-Release Approaches for Potential Treatment of Colorectal Cancer, Pharmaceutical Development and Technology (2021)
50. Preparation and in Vitro/In Vivo Evaluation of Dextran Matrix Tablets of Budesonide in Experimental Ulcerative Colitis in Rats, Drug Delivery (2011)