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Hiv-1 Entry Inhibitors: A Review of Experimental and Computational Studies Publisher Pubmed



Mostashari Rad T1 ; Saghaie L1 ; Fassihi A1, 2
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Bioinformatics and Systems Biology Department, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Chemistry and Biodiversity Published:2018


Abstract

The HIV-1 life cycle consists of different events, such as cell entry and fusion, virus replication, assembly and release of the newly formed virions. The more logical way to inhibit HIV transmission among individuals is to inhibit its entry into the immune host cells rather than targeting the intracellular viral enzymes. Both viral and host cell surface receptors and co-receptors are regarded as potential targets in anti-HIV-1 drug design process. Because of the importance of this topic it was decided to summarize recent reports on small-molecule HIV-1 entry inhibitors that have not been considered in the latest released reviews. All the computational studies reported in the literature regarding HIV-1 entry inhibitors since 2014 was also considered in this review. © 2018 Wiley-VHCA AG, Zurich, Switzerland
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