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Electrophoretically Deposited Mesoporous Magnesium Silicate With Ordered Nanopores As an Antibiotic-Loaded Coating on Surface-Modified Titanium Publisher Pubmed



Bigham A1 ; Saudi A2 ; Rafienia M3 ; Rahmati S4 ; Bakhtiyari H1 ; Salahshouri F1 ; Sattary M5 ; Hassanzadehtabrizi SA1
Authors
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Authors Affiliations
  1. 1. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  2. 2. Student Research Committee, School of Advanced Medical Technologies, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Young Researchers and Elite Club, Shahreza Branch, Islamic Azad University, Shahreza, Iran
  5. 5. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine (ATiM), Isfahan University of Medical Sciences, Isfahan, Iran

Source: Materials Science and Engineering C Published:2019


Abstract

Infection is quite usual for implants after surgery and a systemic administration of antibiotics causes problems before the eradication of bacteria. Localized drug delivery from implants is an effective way by which the mentioned target can be met. In the current work, ordered mesoporous magnesium silicate (OMMS) is coated on plasma electrolytic oxidation (PEO)-modified titanium (Ti) substrate through electrophoretic deposition (EPD) and rifampin as an antibiotic is loaded on OMMS coating to be applied as an antibacterial coating. The immersion test into simulated body fluid and also potentiodynamic polarization assay are adopted to assess the in vitro bioactivity up to 7 days and corrosion resistance of the specimens, respectively. The double surface coatings of PEO and EPD are achieved on Ti substrate and the thickness for each one is found to be 4 and 25 μm, respectively. Regarding to drug delivery capability of OMMS as the EPD coating, the loading capacity is 25% and release trend sustains up to 96 h. The antibacterial activity and also cell viability of OMMS coating are significantly increased with rifampin loading. The results of our study exhibit that OMMS as a multifunctional coating deposited on the PEO-modified Ti substrate improves corrosion resistance, in vitro bioactivity, alkaline phosphatase activity, and mineralization of the substrate. Moreover, rifampin-loaded OMMS coating is not only able to prevent infection, but it also increases the osteogenesis cells viability. Therefore, rifampin-loaded OMMS coating on Ti is potentially regarded appropriate for orthopedic applications. © 2018 Elsevier B.V.
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