Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prevalence, Incidence, and Risk Factors of Nephropathy in Patients With Prediabetes: Family History of Diabetes Mellitus Is Not Associated With Increased Risk of Nephropathy Publisher



Abbasi S1 ; Amini M2 ; Vahdat S1 ; Aminorroaya A3 ; Mortazavi M4 ; Azimi F1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Kidney Disease Research Center, School of Medicine, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Internal Medicine and Endocrinology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Jundishapur Journal of Chronic Disease Care Published:2024


Abstract

Background: Nephropathy, a vascular complication of hyperglycemia in patients with diabetes mellitus (DM) and prediabetes, is the leading cause of chronic kidney disease. Objectives: This study aimed to investigate the incidence and prevalence of nephropathy and its risk factors in patients with prediabetes, with a particular focus on exploring the association between a family history (FH) of DM and nephropathy. Methods: In this retrospective study, we examined the medical records of 819 patients with prediabetes referred to the Isfahan Endocrine and Metabolism Research Center in 2004. We compared the prevalence of nephropathy in 2019 to baseline levels and assessed factors such as FH of DM in first-degree relatives and other nephropathy-related factors among patients with and without nephropathy. Results: The prevalence of nephropathy increased from 39% to 60.6% over 15 years, with a cumulative incidence of 21.6% and a mean annual incidence of 2.4%. There were differences in diastolic and systolic blood pressure, lipid markers, fasting and postprandial glucose levels, and glomerular filtration rate between patients with and without nephropathy; however, these differences were not statistically significant (P-value ≥ 0.05). Male sex (Odds ratio [OR]: 1.8), age (OR: 1.02), and Body Mass Index (BMI) (OR: 1.05) were significantly associated with nephropathy (P-value < 0.05). No significant association was found between a positive FH of DM and nephropathy (P-value = 0.638). Conclusions: Our findings indicate that a FH of DM is not associated with an increased risk of nephropathy in patients with prediabetes. Instead, sex, age, and BMI play a more significant role. Therefore, these factors may be more critical in guiding preventive and treatment measures. © 2024, Abbasi et al.
Related Docs
View other Related Docs
1. Serum Uric Acid Level and Its Association With Cardiometabolic Risk Factors in Prediabetic Subjects, Journal of Research in Medical Sciences (2014)
2. Association Between Adherence to the Mediterranean Diet and Renal Function Biomarkers and Cardiovascular Risk Factors Among Diabetic Patients With Nephropathy, Clinical Nutrition ESPEN (2020)
3. The Association Between Fast-Food Consumption With Cardiovascular Diseases Risk Factors and Kidney Function in Patients With Diabetic Nephropathy, Journal of Cardiovascular and Thoracic Research (2021)
4. Incidence of Microalbuminuria and Associated Risk Factors in Type 2 Diabetes Mellitus, Iranian Journal of Diabetes and Lipid Disorders (2006)
5. Is Uric Acid an Indicator of Metabolic Syndrome in the First-Degree Relatives of Patients With Type 2 Diabetes?, Journal of Research in Medical Sciences (2012)
6. Factors Associated With Progression to Pre-Diabetes: A Recurrent Events Analysis, Eating and Weight Disorders (2020)
7. Prevalence and Risk Factors of Diabetes, Pre-Diabetes and Metabolic Syndrome in First-Degree Relatives of Patients With Type Ii Diabetes, Journal of Kerman University of Medical Sciences (2013)
8. Assessment of Caring Status for Patients With Type 2 Diabetes in Under Control Health Centers of Jarghoyee Region in Isfahan, Iran, Journal of Isfahan Medical School (2017)
Experts (# of related papers)
View all Related Experts
Mojgan Mortazavi (13)
Bijan Iraj (10)
Other Related Docs
9. Assessment and Comparison of the Antioxidant Defense System in Patients With Type 2 Diabetes, Diabetic Nephropathy and Healthy People: A Case–Control Study, Clinical Nutrition ESPEN (2020)
10. Association of Dietary Acid Load With Cardiovascular Disease Risk Factors in Patients With Diabetic Nephropathy, Nutrition (2015)
11. First-Degree Relatives of Patients With Type 2 Diabetes Mellitus and Risk of Non-Alcoholic Fatty Liver Disease, Review of Diabetic Studies (2007)
12. Comparison of Urinary N-Acetyl-Beta-D-Glucosaminidase in Non-Diabetic Subjects and Type2 Diabetic Patients, Iranian Journal of Endocrinology and Metabolism (2011)
13. Progression to Impaired Glucose Metabolism in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran, Diabetes/Metabolism Research and Reviews (2009)
14. Association of Dietary Antioxidant Indices With Kidney Function Indicators in Patients With Type 2 Diabetes: A Cross-Sectional Study, Scientific Reports (2024)
15. Variations in Diabetes Prevalence in Low-, Middle-, and High-Income Countries: Results From the Prospective Urban and Rural Epidemiological Study, Diabetes Care (2016)
16. Determinants of Incident Prediabetes and Type 2 Diabetes in a 7-Year Cohort in a Developing Country: The Isfahan Cohort Study, Journal of Diabetes (2015)
17. Glomerular Hyperfiltration As Predictor of Cardiometabolic Risk Factors Among Children and Adolescents: The Childhood and Adolescence Surveillance and Prevention of Adult⇑V Study, International Journal of Preventive Medicine (2018)
18. Metabolic Syndrome in First Degree Relatives of Patients With Type 2 Diabetes: Incidence and Risk Factors, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2011)
19. Prevalence of Macro- and Microvascular Complications Among Patients With Type 2 Diabetes in Iran: A Systematic Review, Diabetes Research and Clinical Practice (2009)
20. Role of Oxidative Stress and Inflammatory Factors in Diabetic Kidney Disease, Iranian Journal of Kidney Diseases (2016)
21. Lipoprotein(A), Type 2 Diabetes and Nephropathy; the Mystery Continues, Journal of Nephropathology (2012)
22. Effect of Sitagliptin on Proteinuria in Patients With Type 2 Diabetes-A Renoprotective Effect of Sitagliptin, Journal of Research in Medical Sciences (2021)
23. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
24. The Relative Frequency, Clinical and Laboratory Findings of Adult Glomerulonephritidies in Tehran, Journal of Research in Medical Sciences (2006)
25. The Association of Hypertriglyceridemic Waist Phenotype With Type 2 Diabetes Mellitus Among Individuals With First Relative History of Diabetes, Journal of Research in Medical Sciences (2011)
26. The Incidence of Microalbuminuria and Its Associated Risk Factors in Type 2 Diabetic Patients in Isfahan, Iran, Review of Diabetic Studies (2007)
27. Does Metabolic Syndrome Increase Contrast‑Induced Nephropathy in Patients With Normal Renal Function?, Journal of Research in Medical Sciences (2024)
28. Cross-Sectional and Longitudinal Assessments of Risk Factors Associated With Hypertension and Moderately Increased Albuminuria Comorbidity in Patients With Type 2 Diabetes: A 9-Year Open Cohort Study, Diabetes, Metabolic Syndrome and Obesity (2019)
29. The Effects of Macronutrient Intake on the Risk of Pre-Diabetes in First- Degree Relatives of Patients With Type 2 Diabetes, Journal of Isfahan Medical School (2014)
30. Hypertension in Type 2 Diabetes Mellitus in Isfahan, Iran: Incidence and Risk Factors, Diabetes Research and Clinical Practice (2005)
31. Factors Associated With Serum Albumin in Diabetes Mellitus Type 2 With Microalbuminuria Using Non-Normal Mixed Models: A Prospective Cohort Study, Iranian Red Crescent Medical Journal (2016)
32. Effect of Angiotensin Receptor Inhibitors on Endothelial Dysfunction Indices in Patients With Diabetic Nephropathy, Journal of Isfahan Medical School (2011)
33. Soy Milk Consumption and Blood Pressure Among Type 2 Diabetic Patients With Nephropathy, Journal of Renal Nutrition (2013)
34. Healthy and Unhealthy Dietary Patterns Are Related to Pre-Diabetes: A Case-Control Study, British Journal of Nutrition (2016)
35. Can Probiotics Supplementation Improve Glycemic and Renal Status in Diabetic Nephropathy? a Systematic Review and Meta-Analysis of Clinical Trials, Endocrine, Metabolic and Immune Disorders - Drug Targets (2022)
36. Sodium-Glucose Co-Transporter 2 Inhibitors (Sglt2i); As a Preventive Factor of Kidney Failure in Patients With Type 2 Diabetes; a Meta-Analysis of Randomized Controlled Trials, Journal of Renal Injury Prevention (2021)
37. Novel Anthropometric Indices for Predicting Type 2 Diabetes Mellitus, BMC Public Health (2024)
38. The Acidity of Early Pregnancy Diet and Risk of Gestational Diabetes Mellitus, Clinical Nutrition (2018)
39. Circulating Β2 and Α1 Microglobulins Predict Progression of Nephropathy in Diabetic Patients: A Meta‐Analysis of Prospective Cohort Studies, Acta Diabetologica (2022)
40. Diabetes and Associated Cardiovascular Risk Factors in Iran: The Isfahan Healthy Heart Programme, Annals of the Academy of Medicine Singapore (2007)
41. Soy-Protein Consumption and Kidney-Related Biomarkers Among Type 2 Diabetics: A Crossover, Randomized Clinical Trial, Journal of Renal Nutrition (2009)
42. Direct Association Between High Fat Dietary Pattern and Risk of Being in the Higher Stages of Chronic Kidney Disease, International Journal for Vitamin and Nutrition Research (2019)
43. Association of Anthropometric Indices With Albumin to Creatinine Ratio and Glomerular Filtration Rate, As Indices of Ckd: A Population-Based Study, Iranian Journal of Kidney Diseases (2024)
44. The Potential of Cardiac Biomarkers, Nt-Probnp and Troponin T, in Predicting the Progression of Nephropathy in Diabetic Patients: A Meta‐Analysis of Prospective Cohort Studies, Diabetes Research and Clinical Practice (2023)
45. Prevalence and Clinical Findings of Biopsy-Proven Glomerulonephritidis in Iran., Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2007)
46. The Relationship Between Serum Ghrelin Levels and Bone Metabolism Markers and Severity Anemia in Non-Diabetic Hemodialysis Patients; a Pilot Study, Journal of Nephropathology (2018)
47. Mortality and Disability-Adjusted Life Years in North Africa and Middle East Attributed to Kidney Dysfunction: A Systematic Analysis for the Global Burden of Disease Study 2019, Clinical Kidney Journal (2024)
48. Association of Glomerular Filtration Rate With Cardiometabolic Risk Factors in Iranian Adolescents Caspian Iii Study, Iranian Journal of Kidney Diseases (2017)
49. Evaluation of Changes in Blood Sugar Levels in a 14-Years Cohort Study of Pre-Diabetic Patients and Its Relation With Diabetes, Tehran University Medical Journal (2021)
50. The Relationship Between Social Factors and Blood Glucose Control in Patients With Type Ii Diabetes in Isfahan Township, Iran, Journal of Isfahan Medical School (2017)