Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention

Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention Publisher

Poorbaferani F ; Bolandi S ; Abdolvand M ; Aghaiekheyrabadi F ; Farhadian N ; Abdolvand S ; Maghool F ; Emami MH ; Fahim A ; Rahimi H ; Amjadi E ; Bon FDN ; Hemati S ; Salehi M

Source: International Journal of Preventive Medicine Published:2025

Abstract

Background: Many studies have reported the oncogenic roles of microRNA (miRNA)-629-5p and miRNA-660-5p in various cancers. This study aimed to elucidate the oncogenic roles of miRNA-629-5p and miRNA-660-5p, focusing on their potential contributions to early colorectal cancer (CRC) detection. Additionally, this research examines the efficacy of Regorafenib and 3,3'-diindolylmethane (DIM) as therapeutic agents aimed at mitigating the oncogenic activities of these miRNAs by influencing their structural and conformational dynamics, thereby offering a preventive strategy against CRC. Methods: The study utilized quantitative real-Time polymerase chain reaction (QRT-PCR) to confirm the overexpression of miR-629-5p and miR-660-5p in 40 CRC tissues compared to 40 standard samples and their association with clinicopathological factors. Molecular docking and molecular dynamics simulation were used to investigate Regorafenib and DIM binding modes to miR-629-5p and miR-660-5p. Results: QRT-PCR showed that miR-629-5p and miR-660-5p were overexpressed in CRC tissues. In silico molecular docking and dynamic simulation strengthened our hypothesis that Regorafenib and DIM were located in the structures of the mentioned miRNAs, resulting in a slight alteration in their structures during the interaction process. Conclusions: The study's findings suggest that miR-629-5p and miR-660-5p may have potential as predictive biomarkers and treatment targets for Preventing CRC and that Regorafenib and DIM may have miRNA binding properties. They indicated a high affinity to miRNA-629-5p compared with miRNA-660-5p created a slight change in its structure and can suppress its activity in CRC. However, extra experimental approaches are needed to approve our hypothesis. © 2025 Elsevier B.V., All rights reserved.

Style	Citing Format
MLA	Poorbaferani F, et al.. "Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention." International Journal of Preventive Medicine, vol. 16, no. , 2025, pp. -.
APA	Poorbaferani F, Bolandi S, Abdolvand M, Aghaiekheyrabadi F, Farhadian N, Abdolvand S, Maghool F, Emami MH, Fahim A, Rahimi H, Amjadi E, Bon FDN, Hemati S, Salehi M (2025). Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention. International Journal of Preventive Medicine, 16(), -.
Chicago	Poorbaferani F, Bolandi S, Abdolvand M, Aghaiekheyrabadi F, Farhadian N, Abdolvand S, Maghool F, et al.. "Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention." International Journal of Preventive Medicine 16, no. (2025): -.
Harvard	Poorbaferani F et al. (2025) 'Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention', International Journal of Preventive Medicine, 16(), pp. -.
Vancouver	Poorbaferani F, Bolandi S, Abdolvand M, Aghaiekheyrabadi F, Farhadian N, Abdolvand S, et al.. Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention. International Journal of Preventive Medicine. 2025;16():-.
BibTex	@article{ author = {Poorbaferani F and Bolandi S and Abdolvand M and Aghaiekheyrabadi F and Farhadian N and Abdolvand S and Maghool F and Emami MH and Fahim A and Rahimi H and Amjadi E and Bon FDN and Hemati S and Salehi M}, title = {Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention}, journal = {International Journal of Preventive Medicine}, volume = {16}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Poorbaferani F AU - Bolandi S AU - Abdolvand M AU - Aghaiekheyrabadi F AU - Farhadian N AU - Abdolvand S AU - Maghool F AU - Emami MH AU - Fahim A AU - Rahimi H AU - Amjadi E AU - Bon FDN AU - Hemati S AU - Salehi M TI - Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention JO - International Journal of Preventive Medicine VL - 16 IS - SP - EP - PY - 2025 ER -

Style

Citing Format

MLA

Poorbaferani F, et al.. "Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention." International Journal of Preventive Medicine, vol. 16, no. , 2025, pp. -.

APA

Poorbaferani F, Bolandi S, Abdolvand M, Aghaiekheyrabadi F, Farhadian N, Abdolvand S, Maghool F, Emami MH, Fahim A, Rahimi H, Amjadi E, Bon FDN, Hemati S, Salehi M (2025). Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention. International Journal of Preventive Medicine, 16(), -.

Chicago

Poorbaferani F, Bolandi S, Abdolvand M, Aghaiekheyrabadi F, Farhadian N, Abdolvand S, Maghool F, et al.. "Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention." International Journal of Preventive Medicine 16, no. (2025): -.

Harvard

Poorbaferani F et al. (2025) 'Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention', International Journal of Preventive Medicine, 16(), pp. -.

Vancouver

Poorbaferani F, Bolandi S, Abdolvand M, Aghaiekheyrabadi F, Farhadian N, Abdolvand S, et al.. Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention. International Journal of Preventive Medicine. 2025;16():-.

BibTex

@article{ author = {Poorbaferani F and Bolandi S and Abdolvand M and Aghaiekheyrabadi F and Farhadian N and Abdolvand S and Maghool F and Emami MH and Fahim A and Rahimi H and Amjadi E and Bon FDN and Hemati S and Salehi M}, title = {Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention}, journal = {International Journal of Preventive Medicine}, volume = {16}, number = {}, pages = {-}, year = {2025} }

RIS

TY - JOUR
AU - Poorbaferani F
AU - Bolandi S
AU - Abdolvand M
AU - Aghaiekheyrabadi F
AU - Farhadian N
AU - Abdolvand S
AU - Maghool F
AU - Emami MH
AU - Fahim A
AU - Rahimi H
AU - Amjadi E
AU - Bon FDN
AU - Hemati S
AU - Salehi M
TI - Mitigating the Oncogenic Roles of Mir-629-5P and Mir-660-5P Through Direct Binding by Two Potential Drug Targets for Colorectal Cancer Prevention
JO - International Journal of Preventive Medicine
VL - 16
IS -
SP -
EP -
PY - 2025
ER -

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Abstract