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Role of Adiponectin in Patients With End-Stage Renal Failure



Beigrezaei S1 ; Heidari M2 ; Tamadon MR3
Authors
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Authors Affiliations
  1. 1. School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Dept. of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Dept. of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran

Source: Koomesh Published:2017

Abstract

Adiponectin is a cytokine produced by the adipose tissue. This collagen-like protein has 244-amino acid and its concentration in plasma of healthy individuals is 5-40 μg/mL. In fact, adiponectin comprises 1% of the total serum protein. Although, adiponectin has anti-inflammatory and anti-atherogenic effects in physiological conditions and plays a key role in lipid and glucose metabolism and energy balance as well. However, in patients with end-stage renal disease, it is not a protector due to the changes in the structure and function, and also is considered as a risk factor. So with regard to the prevalence of atherosclerosis in patients with end stage renal disease, adiponectin may be a marker for indentifying the cardiovascular involvement of these patients. © 2017, Semnan University of Medical Sciences. All rights reserved.
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