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Effect of Acute and Chronic Hypertension on Short- and Long-Term Spatial and Avoidance Memory in Male Rats Publisher



Ghavipanjeh GR1 ; Alaei H1 ; Khazaei M1 ; Pourshanazari AA2 ; Hoveida R3
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  3. 3. Department of Biology, Faculty of Science, Islamic Azad University of Dourod, Dourod, Lorestan, Iran

Source: Pathophysiology Published:2010


Abstract

It has been demonstrated that hypertension can lead to coronary heart disease, heart failure, stroke, and memory loss. In this study we investigated the effect of acute and chronic hypertension on the avoidance and spatial learning and memory in rats. The forty male rats were divided into acute hypertensive, chronic hypertensive and control for each group rats. Hypertension was induced by Deoxy Corticosterone Acetate (DOCA)-salt method. DOCA was injected 30 mg/kg of body weight subcutaneously, twice a week. These rats received NaCl 1% instead of tap water for drinking throughout the experiment. The control group received normal saline injection with usual drinking water. Spatial learning and memory was investigated by Morris water maze test and passive avoidance learning by Shuttle box test in the rats after hypertension induction. Results showed that acute hypertension impaired short-term memory in passive avoidance learning. However, acute and chronic hypertension did not affect spatial learning and memory. These data suggest that simple uncomplicated hypertension does not remarkably alter cognition. © 2009 Elsevier Ireland Ltd. All rights reserved.
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