The Correlation Between the Histopathological Findings of Endometrial Curettage and Hysterectomy; [میزان تطابق بین یافته های هیستوپاتولوژی کورتاژ اندومتر و هیسترکتومی] Publisher



Derakhshan M¹ ; Rostami A² ; Hedayat P¹ ; Shahrezaie SE¹
Source: Journal of Isfahan Medical School Published:2023

Abstract

Background: Dilatation and curettage (D&C) has been the method of choice for obtaining endometrial sample but there is a challenge about the D&C's accuracy and reliability compared to other diagnostic methods. The aim of this study was to investigate the concordance between endometrial histopathological diagnosis from D&C and hysterectomy samples. Methods: In this retrospective study, histopathological results of D&C samples of 136 women who suffered from abnormal uterine bleeding between 2015 to 2018 and underwent hysterectomy were investigated and compared with pathologic reports of hysterectomy. Findings: The mean ± standard deviation (SD) of age of patients was 52.6 ± 11.3 years in the range of 33-80 years. According to the findings of D&C in comparison with the standard method of hysterectomy, the specificity and negative predictive values were substantial in premalignant samples. Beside, D&C findings revealed the specificity and the positive predictive values as likely as 100% for diagnosing malignant samples. In the other hand, D&C revealed significant the sensitivity and the positive predictive values for diagnosing normal and benign samples. In the premalignant pathologies that were diagnosed with D&C, the risk of an undetected malignancy in the atypical hyperplasia was 16.7%.. Conclusion: No malignant pathology was encountered in patient with a diagnosis of normal tissue or a benign pathology on the D&C samples. In addition, both the specificity and the positive predictive values following D&C was 100% in diagnosing endometrial malignancy. © 2023 Isfahan University of Medical Sciences(IUMS). All rights reserved.