Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits

Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits Pubmed

Ahmadi A¹ ; Naderi GA^{2, 3, 4} ; Asgary S²

Source: Drugs under Experimental and Clinical Research Published:2005

Abstract

HESA-A, a marine compound, has been shown to exhibit antihepatic cancer, antitumor and anti-Parkinson effects. The hepatoprotective potential of HESA-A pretreatment at doses of 125 mg and 250 mg per day orally for a period of 40 days was evaluated against thioacetamide-induced liver damage in rabbits. Biochemical parameters such as serum glutamate oxaloacetate transaminase and lactate dehydrogenase in serum were estimated to assess liver function and lipid peroxidation products (malondialdehyde [MDA]) and the antierythrocyte lysis effect of plasma for measurement of antioxidant potential capacity. Data on the hepatic biochemical parameters revealed the hepatoprotective potential of HESA-A pretreatment against thioacetamide-induced hepatotoxicity in rabbits. There was an increase in total antioxidant and antierythrocyte lysis and a decrease in MDA in plasma after HESA-A treatment. These results strongly suggest that HESA-A has a protective action against preoperative damage to biomembranes. © 2005 Bioscience Ediprint Inc.

Style	Citing Format
MLA	Ahmadi A, Naderi GA, Asgary S. "Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits." Drugs under Experimental and Clinical Research, vol. 31, no. 1, 2005, pp. 1-6.
APA	Ahmadi A, Naderi GA, Asgary S (2005). Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits. Drugs under Experimental and Clinical Research, 31(1), 1-6.
Chicago	Ahmadi A, Naderi GA, Asgary S. "Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits." Drugs under Experimental and Clinical Research 31, no. 1 (2005): 1-6.
Harvard	Ahmadi A, Naderi GA, Asgary S (2005) 'Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits', Drugs under Experimental and Clinical Research, 31(1), pp. 1-6.
Vancouver	Ahmadi A, Naderi GA, Asgary S. Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits. Drugs under Experimental and Clinical Research. 2005;31(1):1-6.
BibTex	@article{ author = {Ahmadi A and Naderi GA and Asgary S}, title = {Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits}, journal = {Drugs under Experimental and Clinical Research}, volume = {31}, number = {1}, pages = {1-6}, year = {2005} }
RIS	TY - JOUR AU - Ahmadi A AU - Naderi GA AU - Asgary S TI - Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits JO - Drugs under Experimental and Clinical Research VL - 31 IS - 1 SP - 1 EP - 6 PY - 2005 ER -

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