Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Hepatoprotective Potential of Hesa-A (A Marine Compound) Pretreatment Against Thioacetamide-Induced Hepatic Damage in Rabbits Pubmed



Ahmadi A1 ; Naderi GA2, 3, 4 ; Asgary S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cancer Research Center, Tehran University of Medical Science, Tehran, Iran
  2. 2. Isfahan Cardiovasc. Research Center, Isfahan Univ. of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Cardiovasc. Research Center, WHO Collaborating Center, Sedigheh Tahereh Hospital, Isfahan, Khorram St., Iran
  4. 4. Isfahan, P. O. Box: 81465-1148, Iran

Source: Drugs under Experimental and Clinical Research Published:2005


Abstract

HESA-A, a marine compound, has been shown to exhibit antihepatic cancer, antitumor and anti-Parkinson effects. The hepatoprotective potential of HESA-A pretreatment at doses of 125 mg and 250 mg per day orally for a period of 40 days was evaluated against thioacetamide-induced liver damage in rabbits. Biochemical parameters such as serum glutamate oxaloacetate transaminase and lactate dehydrogenase in serum were estimated to assess liver function and lipid peroxidation products (malondialdehyde [MDA]) and the antierythrocyte lysis effect of plasma for measurement of antioxidant potential capacity. Data on the hepatic biochemical parameters revealed the hepatoprotective potential of HESA-A pretreatment against thioacetamide-induced hepatotoxicity in rabbits. There was an increase in total antioxidant and antierythrocyte lysis and a decrease in MDA in plasma after HESA-A treatment. These results strongly suggest that HESA-A has a protective action against preoperative damage to biomembranes. © 2005 Bioscience Ediprint Inc.
Related Docs
View other Related Docs
1. Antioxidant Effect of Turmeric and Saffron on the Oxidation of Hepatocytes, Ldl and Non-Enzymatic Glycation of Hemoglobin, Journal of Medicinal Plants (2005)
2. Antioxidant Effect of Ziziphus Vulgaris, Portulaca Oleracea, Berberisintegerima and Gundelia Tournefortti on Lipid Peroxidation, Hb Glycosylation and Red Blood Cell Hemolysis, Journal of Medicinal Plants (2011)
3. Hepatoprotective Effect of Silybum Marianum (L.) Gaertn. and Glycyrrhiza Glabra L. in the Rats, Journal of Medicinal Plants (2005)
4. Cytotoxicity and Antitumor Properties of a Marine Compound, Hesa-A, on Cancer Cells, Daru (2003)
5. Thymoquinone Mitigates Diclofenac-Induced Hepatorenal Toxicity in Male Wistar Rats by Balancing the Redox State and Modulating Bax/Bcl-2/Caspase-3 Apoptotic Pathways and Nf-Κb Signaling, Research in Pharmaceutical Sciences (2025)
6. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
7. Effects of Ferulago Angulata Extract on Serum Lipids and Lipid Peroxidation, Evidence-based Complementary and Alternative Medicine (2014)
8. Sustained Feeding of a Diet High in Fat Resulted in a Decline in the Liver's Insulin-Degrading Enzyme Levels in Association With the Induction of Oxidative and Endoplasmic Reticulum Stress in Adult Male Rats: Evaluation of 4-Phenylbutyric Acid, Heliyon (2024)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (8)
Gholamreza Dashti (2)
Other Related Docs
9. Has Vitamin E Any Shreds of Evidence in Cisplatin-Induced Toxicity, Journal of Biochemical and Molecular Toxicology (2019)
10. Hesa-A: New Treatment for Breast Cancer and Choroidal Metastasis, Medical Science Monitor (2005)
11. The Effects of Livercare Tablet [Combination of Milk Thistle, Dandelion, Barberry, Tumeric (Curcumin), and Artichoke] in Prevention of Anti-Tuberculosis Drugs-Induced Hepatotoxicity: A Randomized Controlled Clinical Trial, Journal of Isfahan Medical School (2021)
12. Toxicity Effect of Holothuria Lessoni Sea Cucumber on Cancerous Mitochondria Obtained From Rat Model of Hepatocellular Carcinoma, Asian Pacific Journal of Cancer Prevention (2024)
13. Solid Dispersion of Hesperetin Co-Crystals Synergistically Attenuates Hepatic Toxicity of Carbon Tetrachloride Oxidative Stress in Rats, Current Drug Delivery (2018)
14. The Role of Vitamin C in Vanadyl-Sulfate-Induced Nephrotoxicity and Hepatotoxicity, Journal of Isfahan Medical School (2016)
15. Antioxidant Activity of Three Extracts of Morus Nigra, Phytotherapy Research (2004)
16. Effect of Pretreatment With a Synbiotic on Perfluorooctanoic Acid-Induced Liver Damage After Sub-Acute Oral Exposure in C57bl/6J Mice, Toxicology and Applied Pharmacology (2023)
17. Effect of a Dietary Supplement Composed of Hydrolyzed Milk Proteins and Vanillin on the Reduction of Infection and Oxidative Stress Induced by Chemotherapy, Journal of Food Biochemistry (2020)
18. Effects of Amirkabiria Odorastissima Mozaffarian on the Development and Progression of Fatty Streaks in Hypercholesterolemic Rabbits, Phytotherapy Research (2004)
19. Hepatoprotective Effects of Iranian Hypericum Scabrum Essential Oils Against Oxidative Stress Induced by Acetaminophen in Rats, Brazilian Archives of Biology and Technology (2014)
20. Antioxidant Effects of Methanol Extract of Dracocephalum Kotschyi in Acetic Acid Induced Rat Colitis Model, Journal of Advances in Medical and Biomedical Research (2022)
21. Hepatotoxicity Effects of Medicinal Plants, New Armenian Medical Journal (2024)
22. Exercise-Activated Hepatic Autophagy Combined With Silymarin Is Associated With Suppression of Apoptosis in Rats Subjected to Dexamethasone Induced- Fatty Liver Damage, Molecular Biology Reports (2024)
23. The Effect of 2,3-Dihydroxybenzoic Acid and Tempol in Prevention of Vancomycin-Induced Nephrotoxicity in Rats, Toxicology (2007)
24. Pretreatment Effect of D-Limonene on Oxidative Stress Induced by Renal Ischemia-Reperfusion Injury in Rats, Journal of Babol University of Medical Sciences (2022)
25. Examining Hepatoprotective Effects of Astaxanthin Against Methotrexate-Induced Hepatotoxicity in Rats Through Modulation of Nrf2/Ho-1 Pathway Genes, Naunyn-Schmiedeberg's Archives of Pharmacology (2024)
26. The Effects of Cornelian Cherry on Atherosclerosis and Atherogenic Factors in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2011)
27. Oxidized Ldl Metabolites With High Family Risk for Premature Cardiovascular Disease, Indian Journal of Pediatrics (2002)
28. The Effects of Astaxanthin Supplementation on Liver Enzyme Levels: A Systematic Review and Meta-Analysis, International Journal for Vitamin and Nutrition Research (2024)
29. Hepatoprotective Effect of Astaxanthin Against Cholestasis Liver Fibrosis Induced by Bile Duct Ligation in Adult Wistar Rats, Journal of Biochemical and Molecular Toxicology (2024)
30. Hepatoprotective Effect of Chichorium Intybus L. on Liver Toxicity in Rat, Journal of Medicinal Plants (2006)
31. Effects of Lactulose and Silymarin on Liver Enzymes in Cirrhotic Rats, Canadian Journal of Physiology and Pharmacology (2017)