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Investigating the Oxidative Stress in Lung Tissue of Male Wistar Rats Exposed to Welding Fumes Publisher



Pourjamalavijeh Z1 ; Rismanchian M2 ; Mohammadalipour A3 ; Karimizeverdegani S2
Authors
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Authors Affiliations
  1. 1. Student Research Committee AND Department of Occupational Health and Safety Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Occupational Health and Safety Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Health System Research Published:2024


Abstract

Background: Welding is a common industrial process that impacts the health status of many workers around the world. The objective of this study was to examine the impact of welding fumes on the levels of antioxidant enzymes, which play a crucial role in lung pathogenesis. Methods: This cross-sectional and experimental research involved producing welding fumes by performing the welding process on a steel piece within a chamber. A personal sampler pump was used to sample the welding fumes, and the filters were analyzed using an inductively coupled plasma-optical emission spectroscopy (ICP-OES) device. In this study, rats were divided into two groups: case and control (each group contained 6 rats). The case group was exposed to fumes for 30 minute/day × 8 days. After the exposure period, their lung tissue was examined using biological kits, and the levels of antioxidant enzymes [glutathione peroxidase (GPx) and superoxide dismutase (SOD)] were measured. Findings: The concentrations of lead (Pb), chromium (Cr), aluminum (Al), copper (Cu), manganese (Mn), and iron (Fe) were 0.131, 0.084, 0.100, 0.019, 2.25, and 12.06 mg/m3, respectively. The average activity of GPx in the control and exposure groups was 16.3438 (mU/mg protein) and 11.81042 (mU/mg protein), respectively. The average activity of SOD in the control and exposure groups was 275.587 (U/mg protein) and 121.168 (U/mg protein), respectively. Conclusion: According to obtained data, welding fumes have a significant effect on reducing the activity of antioxidant enzymes and causing mild to severe damage to lung tissue. © 2024, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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