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Retinal Optical Coherence Tomography in Neuromyelitis Optica Publisher



Oertel FC1, 2 ; Specovius S1 ; Zimmermann HG1 ; Chien C1, 3 ; Motamedi S1 ; Bereuter C1 ; Cook L1 ; Lana Peixoto MA4 ; Fontanelle MA4 ; Kim HJ5 ; Hyun JW5 ; Palace J6, 7 ; Rocafernandez A6 ; Leite MI1 Show All Authors
Authors
  1. Oertel FC1, 2
  2. Specovius S1
  3. Zimmermann HG1
  4. Chien C1, 3
  5. Motamedi S1
  6. Bereuter C1
  7. Cook L1
  8. Lana Peixoto MA4
  9. Fontanelle MA4
  10. Kim HJ5
  11. Hyun JW5
  12. Palace J6, 7
  13. Rocafernandez A6
  14. Leite MI1
  15. Sharma S1
  16. Ashtari F8
  17. Kafieh R1
  18. Dehghani A1
  19. Pourazizi M1
  20. Pandit L9
  21. Dcunha A9
  22. Aktas O10
  23. Ringelstein M1
  24. Albrecht P10
  25. May E11
  26. Tongco C11
  27. Leocani L1
  28. Pisa M1
  29. Radaelli M12
  30. Martinezlapiscina EH1
  31. Stiebelkalish H13, 14
  32. Siritho S15
  33. De Seze J16
  34. Senger T1
  35. Havla J17
  36. Marignier R18
  37. Calvo AC18, 19
  38. Bichuetti D20
  39. Tavares IM20
  40. Asgari N21, 22
  41. Soelberg K22
  42. Altintas A23
  43. Yildirim R1
  44. Tanriverdi U23
  45. Jacob A24, 25
  46. Huda S24
  47. Rimler Z26
  48. Reid A26
  49. Maodraayer Y27
  50. Soto De Castillo I28
  51. Petzold A29
  52. Green AJ1
  53. Yeaman MR30, 31, 32
  54. Smith T33, 34
  55. Brandt AU35
  56. Paul F36
Show Affiliations
Authors Affiliations
  1. 1. Experimental and Clinical Research Center, Max Delbruck Center for Molecular Medicine and Charite–Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Germany
  2. 2. NeuroCure Clinical Research Center, Charite–Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Germany
  3. 3. Department of Neurology, University of California, San Francisco, CA, United States
  4. 4. Department of Pediatrics, University of Utah, Salt Lake City, United States
  5. 5. CIEM MS Research Center, University of Minas Gerais, Medical School, Belo Horizonte, Brazil
  6. 6. Department of Neurology, National Cancer Center, Goyang, South Korea
  7. 7. Department of Neurology, Department of Ophthalmology, Department of Ophthalmology, Oxford University Hospitals, National Health Service Trust, United Kingdom
  8. 8. Kashani MS Center, School of Advanced Technologies in Medicine and Medical Image and Signal Processing Research Center, Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Iran
  9. 9. Department of Neurology, KS Hegde Medical Academy, Nitte University, Mangalore, India
  10. 10. Department of Neurology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
  11. 11. Swedish Neuroscience Institute Neuro-Ophthalmology, Seattle, WA, United States
  12. 12. Experimental Neurophysiology Unit, Inst. of Exp. Neurol. Sci. Institute Hospital San Raffaele and University Vita-Salute San Raffaele, Milan, Italy
  13. 13. Hospital Clinic of Barcelona-Institut d'Investigacions, Biomediques August Pi Sunyer, (IDIBAPS), Spain
  14. 14. Sackler School of Medicine, Tel Aviv University, Israel
  15. 15. Neuro-Ophthalmology Division, Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel
  16. 16. Division of Neurology, Department of Medicine, Siriraj Hospital and Bumrungrad International Hospital, Bangkok, Thailand
  17. 17. Neurology Service, University Hospital of Strasbourg, France
  18. 18. Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians Universitaet Muenchen, Munich, Germany
  19. 19. Neurology, Multiple Sclerosis, Myelin Disorders and Neuroinflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, France
  20. 20. Centre d'Esclerosi Multiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Spain
  21. 21. Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil
  22. 22. Departments of Neurology, Slagelse Hospitals, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
  23. 23. Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
  24. 24. Department of Neurology, Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Turkiye
  25. 25. The Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
  26. 26. The Cleveland Clinic Abu Dhabi, United Arab Emirates
  27. 27. NYU Multiple Sclerosis Comprehensive Care Center, Department of Neurology, NYU School of Medicine, New York, United States
  28. 28. Department of Neurology, University of Michigan Medical School, Ann Arbor, United States
  29. 29. Department of Neurology, Hospital Clinico de Maracaibo, Venezuela, Venezuela
  30. 30. Moorfield's Eye Hospital, University College, London, United Kingdom
  31. 31. Department of Medicine, Los Angeles Biomed. Res. Institute at Harbor-University of California at Los Angeles Medical Center, Torrance, CA, United States
  32. 32. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
  33. 33. Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, United States
  34. 34. Division of Metabolism, Endocrine and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States
  35. 35. Department of Neurology, University of California, Irvine, United States
  36. 36. Department of Neurology, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Germany

Source: Neurology: Neuroimmunology and NeuroInflammation Published:2021


Abstract

Background and ObjectivesTo determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts.MethodsThe cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 healthy controls (HCs). Participants underwent OCT with central reading including quality control and intraretinal segmentation. The primary outcome was thickness of combined ganglion cell and inner plexiform (GCIP) layer; secondary outcomes were thickness of peripapillary retinal nerve fiber layer (pRNFL) and visual acuity (VA).ResultsEyes with ON (NMOSD-ON, N = 260) or without ON (NMOSD-NON, N = 241) were assessed compared with HCs (N = 136). In NMOSD-ON, GCIP layer (57.4 ± 12.2 m) was reduced compared with HC (GCIP layer: 81.4 ± 5.7 m, p < 0.001). GCIP layer loss (-22.7 m) after the first ON was higher than after the next (-3.5 m) and subsequent episodes. pRNFL observations were similar. NMOSD-NON exhibited reduced GCIP layer but not pRNFL compared with HC. VA was greatly reduced in NMOSD-ON compared with HC eyes, but did not differ between NMOSD-NON and HC.DiscussionOur results emphasize that attack prevention is key to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies ameliorating attack-related damage, especially during a first attack, are an unmet clinical need. Mild signs of neuroaxonal changes without apparent vision loss in ON-unaffected eyes might be solely due to contralateral ON attacks and do not suggest clinically relevant progression but need further investigation. © American Academy of Neurology.
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