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Level of Oxidative Stress Markers Among Physicians in a Medical Residency Program Publisher Pubmed



Rostami A1 ; Boojar MMA2 ; Adibi P3 ; Changiz T4
Authors
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Authors Affiliations
  1. 1. The Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  2. 2. The Department of Biology, University of Tarbiat Moalem, Tehran, Iran
  3. 3. The Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. The Department of Pharmacology and Medical Education, Medical Education Research Center, Isfahan University of Medical Sciences, United States

Source: Archives of Environmental and Occupational Health Published:2008


Abstract

The authors investigated the effect of engaging in a medical residency program, as a stressful situation, on blood and urine levels of oxidative stress markers. Newly admitted medical residents participated in the study, along with a control group of (nonmedical) students. The authors assessed superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, micronuclei test, sister chromatid exchange, and 8-hydroxy-2'-deoxyguanosine level. All the biomarkers declined after entrance to the residency program, and the parameters were strongly higher in residents than in the control group. There was no significant relationship between demographic factors and levels of stress biomarkers. The greater extent of oxidative stress may be due to higher tension before entrance to a supposedly critical new position, and the declined levels of biomarkers seen after several months in the program could be attributed to an appropriate adjustment of the residents to the new situation. © 2008 Heldref Publications.