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Resolution of Sperm Quality Impairment Following Sars-Cov-2 Infection: A Prospective Study Publisher



Derakhshan M1, 2 ; Derakhshan M1, 2 ; Naghshineh E1, 2 ; Movahedi M1 ; Ghasemitehrani H1 ; Bamarinejad F4 ; Bamarinejad A4 ; Omidvar Z4
Authors
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Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology/Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Shahid Beheshti Fertility Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Asian Pacific Journal of Reproduction Published:2024


Abstract

Objective: To investigate the length of time required to resolve COVID-19 effects on semen quality and DNA integrity. Methods: A prospective cohort study was conducted among 42 men who tested positive for SARS-CoV-2 and underwent semen analysis at baseline and four months’ post-recovery. Semen samples were collected and evaluated for macroscopic and microscopic parameters, sperm chromatin maturation, and DNA fragmentation. Results: The mean age of participants was 37(±7) years, and 14% had normozoospermia at baseline. After a four-month recovery from COVID-19, 48% of patients had normozoospermia. Sperm count, motility, and morphology increased significantly, while sperm DNA fragmentation and sperm chromatin maturation decreased significantly post-recovery from COVID-19. Conclusions: Sperm parameters improve after a four-month recovery from COVID-19. The findings indicate significant improvements in sperm count, motility, morphology, DNA fragmentation, and chromatin maturation after a four-month recovery period. ©2024 Asian Pacific Journal of Reproduction.
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