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Serum Mmp-9 Level Associated With Initiation and Progression Steps of Breast Cancer in the Iranian Population Publisher Pubmed



Motovalibashi M1 ; Sadeghi M1 ; Hemmati S2
Authors
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Authors Affiliations
  1. 1. Biology Department, Genetic Division, University of Isfahan, Isfahan, Iran
  2. 2. Radiology Oncology Department, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Reproductive Sciences Published:2010


Abstract

Blood matrix metalloproteinase 9 (MMP-9) level is a promising new diagnostic marker. The aim of the current caseg-control study is to investigate the correlation between the serum MMP-9 level with occurrence and progression of breast cancer. The serum MMP-9 level was investigated by gelatin zymography in 100 patients with breast cancer and 120 healthy participants. The average value of MMP-9 activity was significantly higher in patients with breast cancer than in control ( P <.002), this value correlates with tumor stage ( P =.005) and tumor size ( P =.012). Our results suggest serum MMP-9 level is a potential diagnostic marker for predicting breast cancer occurrence and progression. © 2010 The Author(s).