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New Mirsinane-Type Diterpenes From Euphorbia Microsciadia Boiss. With Inhibitory Effect on Vegf-Induced Angiogenesis Publisher Pubmed



Ghanadian SM1 ; Ayatollahi AM2 ; Afsharypuor S3 ; Javanmard SH4 ; Dana N4
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Phytochemistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Natural Medicines Published:2013


Abstract

Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O- (2′-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on 13C- and 1H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation. © 2012 The Japanese Society of Pharmacognosy and Springer.
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