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The Face of Hypervirulent Klebsiella Pneumoniae Isolated From Clinical Samples of Two Iranian Teaching Hospitals Publisher Pubmed



Sanikhani R1 ; Moeinirad M2 ; Solgi H3 ; Hadadi A4 ; Shahcheraghi F1 ; Badmasti F1, 5
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Authors Affiliations
  1. 1. Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Division of Bacteriology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Division of Clinical Microbiology, Department of Laboratory Medicine, Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Sina Hospital, Internal Medicine Department, and Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran

Source: Annals of Clinical Microbiology and Antimicrobials Published:2021


Abstract

Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a pathogen of global concern. In this study, both phenotypic and genotypic tests were used to detect hvKp. Antimicrobial resistance profiles and clonal relatedness of clinical isolates were also determined. We found that 34.2% (163/477) of the isolates were tellurite resistant, and among them 102 hvKp isolates detected with iucA or iutA or peg-344 as molecular markers. The blaSHV (80.4%), followed by blaCTX-M-15 (76.5%) and blaTEM (67.6%), blaOXA-48 (53.9%), and blaNDM-1 (32.3%) were detected, while blaKPC-1 was not present in any hvKp isolates. It was found that the majority of hvKp isolates belonged to capsular serotype K20 and ompK36 group C, which is related to clonal group (CG) 23 (e.g. ST23). A high percentage of multidrug-resistant hvKp (76.6%) and high resistance to imipenem (67%) indicated a serious problem that should be addressed in the clinical setting. © 2021, The Author(s).
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