Moderately Hyperglycemia As an Independent Prognostic Factor for the Worse Outcome of Covid-19 Publisher Pubmed



Nateghi S¹ ; Gomari MM² ; Roudsari YJ¹ ; Foroughi A¹ ; Mansouri F³ ; Shiva A¹ ; Nasrollahizadeh A⁴ ; Nasiri Z¹ ; Faraji N¹ Show Affiliations
Source: Primary Care Diabetes Published:2022

Abstract

Background: Blood sugar (BS) has been proposed as a prognostic factor for COVID-19. In this historical cohort study we evaluated the association between admission time BS and COVID-19 outcome. Methods: First, hospitalized COVID-19 patients were divided into three groups; Non-diabetic patients with BS < 140 mg/dl (N = 394), non-diabetic patients with BS ≥ 140 mg/dl (N = 113) and diabetic patients (N = 315). Mortality, ICU admission, and length of hospital stay were compared between groups and odds ratio was adjusted using logistic regression. Results: After adjustment with pre-existing conditions and drugs, it was shown that non-diabetic patients with BS ≥ 140 mg/dl are at increased risk of mortality (aOR 1.89 (0.99–3.57)) and ICU admission (aOR 2.62 (1.49–4.59)) even more than diabetic patients (aOR 1.72 (1.07–2.78) for mortality and aOR 2.28 (1.47–3.54) for ICU admission. Conclusions: Admission time hyperglycemia predicts worse outcome of COVID-19 and BS ≥ 140 mg/dl is associated with a markedly increase in ICU admission and mortality. © 2022 Primary Care Diabetes Europe