Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Gundelia Tournefortii L. on Some Cardiovascular Risk Factors in Animal Model



Asgary S1 ; Movahedian A2 ; Badiee A2 ; Naderi GH3 ; Amini F3 ; Hamidzadeh Z2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Applied Physiology Research Center Isfahan, Isfahan University of Medical Sciences, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Cardiovascular Research Center, Isfahan, Iran

Source: Journal of Medicinal Plants Published:2008

Abstract

Background: There is no certain result in the field of industrial pharmacy approaching to find effective drugs in prevention and treatment of atherosclerosis, like the control of lipid factors that are a major risk factors of atherosclerosis. Also the tendency of people to use herbal medicine is increasing. Objective: In this study effect of Gundelia tourenfortii L. on some cardiovascular risk factors in animal model assigned by analysis of biochemical factors. Methods: Twenty male rabbits were randomly divided in to 4 groups as: Normal diet, Normal diet supplemented with Gundelia tourenfortii L., high cholesterol diet, and high cholesterol diet supplemented with Gundelia tourenfortii L. Fasting Blood samples were taken at the first and end of the study. Results: Gundelia tourenfortii L. decrease the cholesterol, triglyceride, LDL-cholesterol, VLDL-Cholesterol, apolipoprotein B, oxidized LDL and factor VII. Also increase the level of HDL-Cholesterol and apolipoprotein A comparing to high cholesterol diet. Conclusion: Gundelia tourenfortii L. by decreasing lipid, lipoproteins and some cardiovascular new risk factors like apolipoprotein B, Oxidized-LDL and coagulation factor decrease atherosclerosis.
Related Docs
View other Related Docs
1. Effect of Gundelia Tournefortii L. on Some Cardiovascular Risk Factors in an Animal Model, Journal of HerbMed Pharmacology (2017)
2. Effect of Opium Addiction on New and Traditional Cardiovascular Risk Factors: Do Duration of Addiction and Route of Administration Matter?, Lipids in Health and Disease (2008)
3. A Review of Plant‑Based Compounds and Medicinal Plants Effective on Atherosclerosis, Journal of Research in Medical Sciences (2017)
4. Effects of Ferulago Angulata Extract on Serum Lipids and Lipid Peroxidation, Evidence-based Complementary and Alternative Medicine (2014)
5. Effect of Artemisia Aucheri Extract on Atherogenic Lipids and Atherogenesis in Hypercholesterolemic Rabbits, Journal of Medicinal Plants (2007)
6. Effect of Artemisia Aucheri on Regression of Atherosclerotic Plaque in Rabbits, Journal of Medicinal Plants (2009)
7. The Effects of Cornelian Cherry on Atherosclerosis and Atherogenic Factors in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2011)
8. Hypocholesterolemic and Antiatherosclerotic Effect of Artemisia Aucheri in Hypercholesterolemic Rabbits, Pakistan Journal of Pharmaceutical Sciences (2010)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (34)
Gholamreza Dashti (10)
Other Related Docs
9. Impact of Sumac on Postprandial High-Fat Oxidative Stress, Pakistan Journal of Medical Sciences (2013)
10. Nigella Sativa L. Improves Lipid Profile and Prevents Atherosclerosis: Evidence From an Experimental Study on Hypercholesterolemic Rabbits, Journal of Functional Foods (2013)
11. Effect of Hydroalcoholic Extract of Hypericum Perforatum on Selected Traditional and Novel Biochemical Factors of Cardiovascular Diseases and Atherosclerotic Lesions in Hypercholesterolemic Rabbits: A Comparison Between the Extract and Lovastatin, Journal of Pharmacy and Bioallied Sciences (2012)
12. Effect of Glycyrrhiza Glabra Extract on Aorta Wall Atherosclerotic Lesion in Hypercholesterolemic Rabbits, Pakistan Journal of Nutrition (2007)
13. Effects of Alfalfa on Lipoproteins and Fatty Streak Formation in Hypercholesterolemic Rabbits, Pakistan Journal of Pharmaceutical Sciences (2008)
14. Lipid Lowering by Hydroalcoholic Extracts of Amaranthus Caudatus L. Induces Regression of Rabbits Atherosclerotic Lesions, Lipids in Health and Disease (2011)
15. Effects of Breads Containing Flaxseeds on Serum Levels of Apelin and Lipids in Hyperlipidemic Patients, Iranian Journal of Nutrition Sciences and Food Technology (2021)
16. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
17. Clinical Effects of Rhus Coriaria Fruits on Dyslipidemia308 in Adolescents: A Triple-Blinded Randomized Placebo-Controlled Trial, Medical archives (Sarajevo, Bosnia and Herzegovina) (2014)
18. The Effects of Concurrent Hydroalcoholic Extract of Amaranthus Caudatus L. and Hypericum Perforatum L. of Fatty Streak Formation in Hypercholesterolemic Animals, African Journal of Pharmacy and Pharmacology (2011)
19. Inverse Association of Legume Consumption and Dyslipidemia: Isfahan Healthy Heart Program, Journal of Clinical Lipidology (2014)
20. The Effect of Hydroalcoholic Extract of Dorema Aucheri on Cd40 Protein Expression in Thoracic Aorta of Male White Rabbits Fed With Hypercholesterolemic Diet, Journal of Isfahan Medical School (2012)
21. Does Supplementation With Pine Bark Extract Improve Cardiometabolic Risk Factors? a Systematic Review and Meta-Analysis, BMC Complementary Medicine and Therapies (2025)
22. The Effect of Brassica Vegetables on Blood Glucose Levels and Lipid Profiles in Adults. a Systematic Review and Meta-Analysis, Phytotherapy Research (2022)
23. Herbs With Anti-Lipid Effects and Their Interactions With Statins As a Chemical Antihyperlipidemia Group Drugs: A Systematic Review, ARYA Atherosclerosis (2015)
24. Nutraceuticals in Hyperlipidemic Children: A Systematic Review and Meta-Analysis, International Journal of Pediatrics (2016)
25. Effect of Vitamin E on Apoptosis of the Endothelial Cells of the Carotid Arteries in Hypercholesterolemic Male Rabbits, ARYA Atherosclerosis (2023)
26. Effects of Dietary Red Clover on Blood Factors and Cardiovascular Fatty Streak Formation in Hypercholesterolemic Rabbits, Phytotherapy Research (2007)
27. A Systematic Review on Safety and Drug Interaction of Herbal Therapy in Hyperlipidemia: A Guide for Internist, Acta Biomedica (2015)
28. An Unhealthy Plant-Based Diet Increases Risk of Hypertension But Not Framingham Risk Score in Adults, Current Developments in Nutrition (2023)
29. Effects of Opium Consumption on Cardiometabolic Diseases, Nature Reviews Cardiology (2013)
30. Effect of Ganoderma Lucidum on Serum Lipid Profiles: A Systematic Review and Meta‑Analysis on Animal Studies, Journal of Research in Medical Sciences (2023)
31. The Effect of Ginger Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Clinical Trials, Phytomedicine (2018)
32. Protective and Curative Effects of Unconjugated Bilirubin on Gene Expression of Lox-1 and Inos in the Heart of Rats Receiving High-Fat Diet and Low Dose Streptozotocin: A Histomorphometric Approach, Journal of Inflammation (United Kingdom) (2024)
33. The Effect of Phytochemicals in Prediabetic Patients: A Systematic Review of Randomized Controlled Trials, Phytotherapy Research (2023)
34. Rice Bran Oil Decreases Total and Ldl Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Hormone and Metabolic Research (2016)
35. Ethanolic Extract of Artemisia Aucheri Induces Regression of Aorta Wall Fatty Streaks in Hypercholesterolemic Rabbits, Pharmazie (2008)
36. Dietary Patterns in Relation to Lipid Profiles Among Iranian Adults, Journal of Cardiovascular and Thoracic Research (2019)
37. Effects of Amaranthus Caudatus L. Extract and Lovastatin on Atherosclerosis in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2010)
38. The Effect of Aspirin on Serum Vascular Endothelial Growth Factor and Nitric Oxide Concentration in High-Cholesterol Fed Rabbits, ARYA Atherosclerosis (2007)
39. Impacts of Fresh Lime Juice and Peel on Atherosclerosis Progression in an Animal Model, ARYA Atherosclerosis (2013)
40. Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum Pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats, Iranian Journal of Pharmaceutical Research (2009)
41. The Efficacy of Dietary Approaches to Stop Hypertension (Dash) Diet on Lipid Profile: A Systematic Review and Meta-Analysis of Clinical Controlled Trials, Current medicinal chemistry (2025)
42. Pomegranate Peel Extract Supplementation Increases the Number of Endothelial Progenitor Cells and Attenuates the Development of Atherosclerosis Plaque, Journal of Isfahan Medical School (2012)
43. Anti-Hyperelipidemic Effects of Sumac (Rhus Coriaria L.): Can Sumac Strengthen Anti-Hyperlipidemic Effect of Statins?, Der Pharmacia Lettre (2016)
44. Portulaca Oleracea Seeds Extract Does Not Prevent Dexamethasone-Induced Hypertension in Rats, Journal of HerbMed Pharmacology (2018)
45. Anethum Graveolens and Hyperlipidemia: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2014)
46. Antioxidant Effect of Ziziphus Vulgaris, Portulaca Oleracea, Berberisintegerima and Gundelia Tournefortti on Lipid Peroxidation, Hb Glycosylation and Red Blood Cell Hemolysis, Journal of Medicinal Plants (2011)
47. Antihypertensive and Antihyperlipidemic Effects of Achillea Wilhelmsii, Drugs under Experimental and Clinical Research (2000)
48. Gender Difference in Endothelial Permeability of Aorta in Rabbits Consuming Normal or High-Cholesterol Diets, Iranian Journal of Medical Sciences (2003)
49. Potential Cardioprotective Effects of Sumac Capsule in Patients With Hyperlipidemia: A Triple-Blind Randomized, Placebo-Controlled Crossover Trial, Journal of the American College of Nutrition (2018)
50. The Effects of Aqueous Extract of Alfalfa on Blood Glucose and Lipids in Alloxan-Induced Diabetic Rats, Interventional Medicine and Applied Science (2015)