Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Influence of Poly (Lactide-Co-Glycolide) Type and Gamma Irradiation on the Betamethasone Acetate Release From the in Situ Forming Systems Publisher Pubmed



Rafienia M1, 4 ; Emami SH2 ; Mirzadeh H2, 3 ; Mobedi H3 ; Karbasi S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Medical Physics and BioMedical Engineering Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81744-176, Iran
  2. 2. Biomedical Engineering Department, Amirkabir University of Technology, Tehran 15875-4413, Iran
  3. 3. Iran Polymer, Petrochemical Institute, Tehran 14965-115, Iran
  4. 4. Medical Physics and Bio-Medical Engineering Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81744-176, Iran

Source: Current Drug Delivery Published:2009


Abstract

In situ forming biodegradable polymeric systems were prepared from Poly (DL-lactide-co-glycolide), RG504H (50:50, lactide:glycolide), RG756 (75:25) and mixture of them. They were dissolved in N-methyl-2-pyrrolidone (33% w/w) and mixed with betamethasone acetate (BTMA, 5 and 10% w/w) and ethyl heptanoate (5% w/w, as an additive). The effects of gamma irradiation, drug loading, type of polymers and solvent removal were evaluated on release profiles. Scanning electron microscopy (SEM) of RG756 samples loaded by BTMA did not show any degradation until two weeks. Differential scanning calorimeter (DSC) experiments confirmed insignificant decrease in Tg, and consequently release rate. Declining Tg of RG504H and RG756 after gamma irradiation was about 0.4 and 1.46°C, respectively. High performance liquid chromatography (HPLC) revealed that BTMA release is more rapid from the formulations prepared using the RG504H with lower molecular weight. The formulations prepared by RG756 had lower burst release (2.5-41%) than the samples based on RG504H (60-67%) and mixture of them (30-33%). Regarding this research three different kinds of steriled in situ forming systems were developed which can release BTMA for 24, 90 and 60 days. © 2009 Bentham Science.
Related Docs
1. Investigation of Drug Release From Biodegradable Polymeric Delivery System by Infrared Spectrometry, International Journal of Polymer Analysis and Characterization (2008)
2. Investigation of Drug Release and 1H-Nmr Analysis of the in Situ Forming Systems Based on Poly(Lactide-Co-Glycolide), Polymers for Advanced Technologies (2009)
3. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
4. Preparation and Characterization of Aligned Porous Pcl/Zein Scaffolds As Drug Delivery Systems Via Improved Unidirectional Freeze-Drying Method, Materials Science and Engineering C (2016)
5. Use of Natural Gums and Cellulose Derivatives in Production of Sustained Release Metoprolol Tablets, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
6. Dual Thermo- and Ph-Responsive Poly(N-Isopropylacrylamide-Co-(2-Dimethylamino) Ethyl Methacrylate)-G-Peg Nanoparticle System and Its Potential in Controlled Drug Release, Polymer Bulletin (2020)
Experts (# of related papers)
View all Related Experts
Hojjat Sadeghi-Aliabadi (2)
Afshin Fassihi (1)