The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze

The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze Publisher Pubmed

Hosseini M¹ ; Headari R² ; Oryan S² ; Hadjzadeh MA¹ ; Saffarzadeh F¹ ; Khazaei M³

Show Affiliations

1. Department of Physiology and Neuroscience Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2. Department of Biology, Faculty of Science, Tarbiat Moallem University of Tehran, Tehran, Iran
3. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Clinics Published:2010

Abstract

OBJECTIVE: The present study was carried out to evaluate the effect of L-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats. METHODS: Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of L-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups. RESULTS: Time latency and path length in the OVX group were significantly higher than in the sham group (P<0.05). The OVX-Est group had a significantly shorter traveled path length and time latency compared to the OVX group (P<0.001). Time latency and path length in the sham-Est group was significantly higher than in the sham group (P<0.001). Time latency and path length in the OVX-Est-LA group were significantly higher than in the OVXEst group. CONCLUSIONS: These results allow us to propose that chronic treatment with estradiol enhances the spatial learning and memory of OVX rats, and that long term L-arginine treatment attenuates the effects of improvement produced by estradiol in OVX rats. © 2010 CLINICS.

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Style	Citing Format
MLA	Hosseini M, et al.. "The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze." Clinics, vol. 65, no. 8, 2010, pp. 803-807.
APA	Hosseini M, Headari R, Oryan S, Hadjzadeh MA, Saffarzadeh F, Khazaei M (2010). The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze. Clinics, 65(8), 803-807.
Chicago	Hosseini M, Headari R, Oryan S, Hadjzadeh MA, Saffarzadeh F, Khazaei M. "The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze." Clinics 65, no. 8 (2010): 803-807.
Harvard	Hosseini M et al. (2010) 'The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze', Clinics, 65(8), pp. 803-807.
Vancouver	Hosseini M, Headari R, Oryan S, Hadjzadeh MA, Saffarzadeh F, Khazaei M. The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze. Clinics. 2010;65(8):803-807.
BibTex	@article{ author = {Hosseini M and Headari R and Oryan S and Hadjzadeh MA and Saffarzadeh F and Khazaei M}, title = {The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze}, journal = {Clinics}, volume = {65}, number = {8}, pages = {803-807}, year = {2010} }
RIS	TY - JOUR AU - Hosseini M AU - Headari R AU - Oryan S AU - Hadjzadeh MA AU - Saffarzadeh F AU - Khazaei M TI - The Effect of Chronic Administration of L-Arginine on the Learning and Memory of Estradiol-Treated Ovariectomized Rats Tested in the Morris Water Maze JO - Clinics VL - 65 IS - 8 SP - 803 EP - 807 PY - 2010 ER -

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