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Efficacy and Toxicity of Flash Radiotherapy: A Systematic Review Publisher Pubmed



Omyan G1 ; Musa AE2 ; Shabeeb D3, 4 ; Akbardoost N5 ; Gholami S1, 2
Authors
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Authors Affiliations
  1. 1. Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Misan Radiotherapy Center, Misan Health Directorate, Ministry of Health/ Environment
  4. 4. Department of Physiology, College of Medicine, University of Misan, Amarah, Iraq
  5. 5. Department of Medical Physics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Cancer Research and Therapeutics Published:2020


Abstract

In recent times, research on the use of ultrahigh-dose rates delivered in super-fast times in cancer treatment has been garnering interest. This has brought about the term 'FLASH' radiotherapy (RT). Thus, in the present study, we systematically review these recent studies on FLASH RT with regard to its efficacy and safety. The reporting of this systematic review was done in line with the statement of Preferred Reporting Items for Systematic reviews and Meta-Analyses. Electronic search of the databases such as PubMed, Scopus, and Embase was conducted to retrieve relevant studies investigating the FLASH effect. From an initial search of 216 potential articles, 16 articles (in vivo, in vitro , and clinical studies) were finally included in this systematic review. Results showed that FLASH RT dose rates had protective effects on normal tissues in addition to antitumor effect. Although still in its early research stages, FLASH RT has the potential to rival present RT regimens in terms of safety and antitumor effect. However, further studies are needed to address the aspects such as optimal dose rate, effect on deep tumors, tumor recurrence, longer follow-up time, and mechanism of action. © 2020 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.
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