Effect of Pomegranate Juice on Vascular Adhesion Factors: A Systematic Review and Meta-Analysis Publisher Pubmed



Asgary S¹ ; Karimi R² ; Joshi T³ ; Kilpatrick KL⁴ ; Moradi S^{5, 6} ; Samimi Z⁷ ; Mohammadi E⁸ ; Bishayee A⁴ ; Farzaei MH⁷ Show Affiliations
Source: Phytomedicine Published:2021

Abstract

Background: Cardiovascular diseases, obesity, and insulin resistance demonstrate elements of functional impairment of the endothelium. Treatment of endothelial dysfunction with natural products, such as pomegranate, can open new ways in the treatment of cardiovascular diseases. Purpose: The present meta-analysis provides information in highlighting the role of pomegranate in endothelial dysfunction. Methods: Various databases, such as PubMed, Scopus, Web of Science, Cochrane, and Google Scholar, were searched up to July 2020 using relevant keywords. We have selected the studies that investigated the effects of pomegranate on vascular adhesion factors, including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and interleukin-6 (IL-6). MD with 95% CrI with 100,000 iterations by using Markov chain Monte Carlo code were used. Results: Pooled effect size of articles in human studies indicated that pomegranate juice was not significantly effective on ICAM-1 [MD: −0.42; CrI: (−1.01, 0.17)], VCAM-1 [MD: −0.20; CrI: (−1.95, 1.40)], and E-selectin [MD: −0.21; CrI: (−1.62, 1.21)] compared to the control group. But it can significantly reduce IL-6 [MD: −1.07; CrI: (−1.90, -0.19)]. Conclusion: Generally, present study showed that pomegranate juice has no significant effect on vascular adhesion factors, ICAM-1, VCAM-1, and E-selectin, but can reduce IL-6 significantly. Future prospective randomized clinical trials with longer intervention duration are warranted to obtain a precise conclusion. © 2020 Elsevier GmbH