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Natural Ampk Activators in Cardiovascular Disease Prevention Publisher



Heidary Moghaddam R1 ; Samimi Z2 ; Asgary S3 ; Mohammadi P4 ; Hozeifi S5 ; Hoseinzadehchahkandak F6 ; Xu S7 ; Farzaei MH2, 8
Authors
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Authors Affiliations
  1. 1. Clinical Research Development Center, Imam Ali and Taleghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  6. 6. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
  7. 7. Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
  8. 8. Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Frontiers in Pharmacology Published:2022


Abstract

Cardiovascular diseases (CVD), as a life-threatening global disease, is receiving worldwide attention. Seeking novel therapeutic strategies and agents is of utmost importance to curb CVD. AMP-activated protein kinase (AMPK) activators derived from natural products are promising agents for cardiovascular drug development owning to regulatory effects on physiological processes and diverse cardiometabolic disorders. In the past decade, different therapeutic agents from natural products and herbal medicines have been explored as good templates of AMPK activators. Hereby, we overviewed the role of AMPK signaling in the cardiovascular system, as well as evidence implicating AMPK activators as potential therapeutic tools. In the present review, efforts have been made to compile and update relevant information from both preclinical and clinical studies, which investigated the role of natural products as AMPK activators in cardiovascular therapeutics. Copyright © 2022 Heidary Moghaddam, Samimi, Asgary, Mohammadi, Hozeifi, Hoseinzadeh‐Chahkandak, Xu and Farzaei.
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