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Protective Effects of the Aqueous Extract of Malva Sylvestris Plant Against the Lethality and Histopathological Damage in Experimental Envenoming of Hemiscorpius Lepturus Venom in Balb/C Mice Publisher Pubmed



Ahmadi SM1 ; Yousofpour M2, 3 ; Kamalinejad M4 ; Otroshi A5 ; Amiri FT6 ; Alipour A7 ; Zareinejad MR8 ; Shahbazzadeh D8
Authors
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Authors Affiliations
  1. 1. Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Department of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Traditional Medicine, Traditional and Complementary Medicine Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Anatomy, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Community Medicine Department, Medical Faculty, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

Source: Current Pharmaceutical Design Published:2024


Abstract

Introduction: Hemiscorpius lepturus envenomation is a serious health problem in the southern provinces of Iran. The antiserum produced in Iran to counteract this scorpion venom is not entirely effective due to the risk of anaphylactic shock and other adverse effects. Methods: Therefore, more efficient alternatives to treat patients deserve attention, and plants are extensively good candidates to be studied. This study aimed to assess the potential of the aqueous fraction of Malva sylvestris in inhibiting the toxic effects of H. lepturus venom. Injection of sub-lethal dose of H. lepturus venom leads to severe tissue damage in vital organs including the kidney, liver, heart and intestine, after 24 hours. Results: By injecting 80 mg of the aqueous extract of M. sylvestris into the peritoneum helped treat the damaged tissues caused by H. lepturus venom in mice. Conclusion: Thus, Malva sylvestris could serve as an alternative treatment for scorpion sting envenomation and may be used as a drug to neutralize relevant toxic effects in patients stung by H. lepturus. © 2024 Bentham Science Publishers.
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