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Characterization of Plga/Chitosan Electrospun Nano-Biocomposite Fabricated by Two Different Methods Publisher



Vaezifar S1, 2 ; Razavi S1 ; Golozar MA2 ; Esfahani HZ3 ; Morshed M4 ; Karbasi S5
Authors
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Authors Affiliations
  1. 1. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81744176, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
  3. 3. Department of Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
  5. 5. Department of Medical Physics and Biomedical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2015


Abstract

Nano-biocomposites composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun using two fabrication methods. In the single nozzle method, the CS nano-powders dispersed in PLGA solutions were electrospun through a single nozzle but in the double-nozzle method, PLGA and CS were simultaneously electrospun from two syringes and the electrospun PLGA nanofiber and electrosprayed CS nanoparticles were mixed and collected on the rotating drum (randomly oriented [A] and aligned [B]) to prepare the nano-biocomposite membrane. The PLGA/CS scaffolds were prepared at the different ratios. The single-nozzle method was associated with decreasing fiber diameter when the CS content was increased and exhibited improve mechanical and hydrophilic properties. © 2015 Taylor & Francis Group, LLC.
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