Changes in Catecholamine Levels of Cerebellum, Mid-Brain and Brain-Cortex in Aluminium Intoxified Rats



Moshtaghie AA¹ ; Rahimi S¹ ; Messripour M¹ Show Affiliations
Source: Indian Journal of Pharmacology Published:1996

Abstract

The short and long term effects of aluminium toxicity on brain catecholamine level was investigated. Rats were injected daily with varying amounts of aluminium and the contents of catecholamine in cerebellum, mid-brain and brain cortex was determined. The short term administration of aluminium (740 μmole/kg) did not have significant effect on catecholamine levels of cerebellum, mid-brain and brain cortex. Catecholamine levels of cerebellum, mid-brain and brain cortex were reduced by 5, 8 and 4 percent in intact male rats given daily dose of 74 μmole/kg of aluminium daily for 15 days. Administration of 74 μmole/kg aluminium for 30 and/or 60 days reduced catecholamine levels of cerebellum 11 to 19%, mid-brain 20 to 38% and brain - cortex 13 to 24% respectively. Examination of rats given higher dose of 185 μmole/kg aluminium daily for 15 and 30 days showed that catecholamine level of cerebellum decreased by 9 to 18%, mid-brain by 13 to 33% and brain cortex by 11 to 22% respectively. It might be concluded that brain disturbances in aluminium intoxified rat occurred through the reduction in the catecholamine levels.